Is pig organ xenotransplantation era approaching?

Zheng Hu , Minghui Fang , Fei Xu , Kazuhiko Yamada , Yong-Guang Yang

Life Medicine ›› 2022, Vol. 1 ›› Issue (3) : 241 -243.

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Life Medicine ›› 2022, Vol. 1 ›› Issue (3) : 241 -243. DOI: 10.1093/lifemedi/lnac032
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Is pig organ xenotransplantation era approaching?

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Zheng Hu, Minghui Fang, Fei Xu, Kazuhiko Yamada, Yong-Guang Yang. Is pig organ xenotransplantation era approaching?. Life Medicine, 2022, 1(3): 241-243 DOI:10.1093/lifemedi/lnac032

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Ekser B, Li P, Cooper DKC. Xenotransplantation: past, present, and future. Curr Opin Organ Transplant 2017;22:513–21.

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Porrett PM, Orandi BJ, Kumar V, et al. First clinical-grade porcine kidney xenotransplant using a human decedent model. Am J Transplant 2022;22:1037–53.

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Montgomery RA, Stern JM, Lonze BE, et al. Results of two cases of pig-to-human kidney xenotransplantation. N Engl J Med 2022;386:1889–98.

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Griffith BP, Goerlich CE, Singh AK, et al. Genetically modified porcine-to-human cardiac xenotransplantation. N Engl J Med 2022;387:35–44.

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Mohiuddin MM, Goerlich CE, Singh AK, et al. Progressive genetic modifications of porcine cardiac xenografts extend survival to 9 months. Xenotransplantation 2022:e12744.

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Adams AB, Lovasik BP, Faber DA, et al. Anti-C5 antibody tesidolumab reduces early antibody-mediated rejection and prolongs survival in renal xenotransplantation. Ann Surg 2021;274:473–80.

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Firl DJ, Markmann JF. Measuring success in pig to non-human-primate renal xenotransplantation: systematic review and comparative outcomes analysis of 1051 life-sustaining NHP renal allo- and xeno-transplants. Am J Transplant 2022;22:1527–36.

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Griesemer A, Yamada K, Sykes M. Xenotransplantation: immunological hurdles and progress toward tolerance. Immunol Rev 2014;258:241–58.

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The Author(s) 2022. Published by Oxford University Press on behalf of Higher Education Press.

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