GSDMD is dispensable for hematopoietic homeostasis and hematopoietic stem cell function

References

[1] Morrison SJ, Scadden DT. The bone marrow niche for haematopoietic stem cells. Nature 2014;505:327–34.

[2] Yang X, Cong T, He H, et al. GSDME maintains hematopoietic stem cells by balancing pyroptosis and apoptosis. Blood Sci 2021;3:40–7.

[3] Yang X, Ge L, Wang J. BECN1 modulates hematopoietic stem cells by targeting Caspase-3-GSDME-mediated pyroptosis. Blood Sci 2020;2:89–99.

[4] Ding J, Wang K, Liu W, et al. Pore-forming activity and structural autoinhibition of the gasdermin family. Nature 2016;535:111–6.

[5] Liu ZZ, Yang YJ, Zhou FH, et al. GSDMD contributes to host defence against Staphylococcus aureus skin infection by suppressing the Cxcl1-Cxcr2 axis. Vet Res 2021;52:71.

[6] Fujii T, Tamura M, Tanaka S, et al. Gasdermin D (Gsdmd) is dispensable for mouse intestinal epithelium development. Genesis 2008;46:418–23.

[7] Wang K, Sun QI, Zhong X, et al. Structural mechanism for GSDMD targeting by autoprocessed caspases in pyroptosis. Cell 2020;180: 941–55.e20.

[8] Shi J, Zhao Y, Wang K, et al. Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death. Nature 2015;526:660–5.

[9] Dai S, Ye B, Zhong L, et al. GSDMD mediates LPS-induced septic myocardial dysfunction by regulating ROS-dependent NLRP3 inflammasome activation. Front Cell Dev Biol 2021;9:779432.

[10] Wang Y, Gao W, Shi X, et al. Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin. Nature 2017;547:99–103.

RIGHTS & PERMISSIONS

2022 The Author(s) 2022. Published by Oxford University Press on behalf of Higher Education Press.