Hidden totipotency in naïve human pluripotent stem cell cultures

References

[1] Macfarlan TS, Gifford WD, Driscoll S, et al. Embryonic stem cell potency fluctuates with endogenous retrovirus activity. Nature 2012;487:57–63.

[2] Hendrickson PG, Doráis JA, Grow EJ, et al. Conserved roles of mouse DUX and human DUX4 in activating cleavage-stage genes and MERVL/HERVL retrotransposons. Nat Genet 2017;49:925–34.

[3] Shen H, Yang M, Li S, et al. Mouse totipotent stem cells captured and maintained through spliceosomal repression. Cell 2021;184:2843–59.

[4] Yang M, Yu H, Yu X, et al. Chemical-induced chromatin remodeling reprograms mouse ESCs to totipotent-like stem cells. Cell Stem Cell 2022;29:400–18.

[5] Xu Y, Zhao J, Ren Y, et al. Derivation of totipotent-like stem cells with blastocyst-like structure forming potential. Cell Res 2022;32: 513–29.

[6] Wang Y, Zhao C, Hou Z, et al. Unique molecular events during reprogramming of human somatic cells to induced pluripotent stem cells (iPSCs) at naïve state. Elife 2018;7:e29518.

[7] Yu L, Wei Y, Duan J, et al. Blastocyst-like structures generated from human pluripotent stem cells. Nature 2021;591:620–6.

[8] Taubenschmid-Stowers J, Rostovskaya M, Santos F, et al. 8C-like cells capture the human zygotic genome activation program in vitro. Cell Stem Cell 2022;29:449–59.

[9] Moya-Jódar M, Ullate-Agote A, Barlabé P, et al. Revealing cell populations catching the early stages of the human embryo development in naïve pluripotent stem cells. bioRxiv 2022.

[10] Mazid MA, Ward C, Luo Z, et al. Rolling back human pluripotent stem cells to an eight-cell embryo-like stage. Nature 2022;605:315–24.

RIGHTS & PERMISSIONS

The Author(s) 2022. Published by Oxford University Press on behalf of Higher Education Press.