When spermatogenesis meets human aging and elevated body mass

References

[1] Xi YP, Nette EG, King DW, et al. Age-related changes in normal human basement mem-brane. Mech Ageing Dev 1982;19:315–24.

[2] Nie X, Munyoki SK, Sukhwani M, et al. Single-cell analysis of human testis aging and correlation with elevated body mass index. Dev Cell 2022;57:1160–76.e5.

[3] Maher GJ, Goriely A, Wilkie AO. Cellular evidence for self-ish sper-matogonial selection in aged human testes. Andrology 2014;2:304–14.

[4] Laurentino S, Cremers JF, Horsthemke B, et al. A germ cell-specific ageing pattern in otherwise healthy men. Aging Cell 2020;19:e13242.

[5] Pohl E, Höffken V, Schlatt S, et al. Ageing in men with normal spermatogenesis alters spermatogonial dynamics and nuclear morphology in Sertoli cells. Andrology 2019;7:827–39.

[6] Cao M, Shao X, Chan P, et al. High-resolution analyses of human sperm dynamic meth-ylome reveal thousands of novel age-related epigenetic alterations. Clin Epigenetics 2020;12:192.

[7] Pohl E, Gromoll J, Wistuba J, et al. Healthy ageing and spermatogenesis. Reproduction 2021;161:R89–101.

[8] Sharma R, Agarwal A, Rohra VK, et al. Effects of increased paternal age on sperm quality, reproductive outcome and associated epigenetic risks to offspring. Reprod Biol Endocrinol 2015;13:35.

[9] Wang B, Wang L, Gasek NS, et al. An inducible p21-Cre mouse model to monitor and manipulate p21-highly-expressing senescent cells in vivo. Nat Aging 2021;1:962–73.

RIGHTS & PERMISSIONS

2022 The Author(s) 2022. Published by Oxford University Press on behalf of Higher Education Press.