Failures at every level: breakdown of the epigenetic machinery of aging

Dongxin Zhao; Song Chen

doi:10.1093/lifemedi/lnac016

Life Medicine ›› 2022, Vol. 1 ›› Issue (2) : 81 -83. DOI: 10.1093/lifemedi/lnac016

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Failures at every level: breakdown of the epigenetic machinery of aging

Dongxin Zhao ¹^,^†
, Song Chen ²^,^†

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Dongxin Zhao, Song Chen. Failures at every level: breakdown of the epigenetic machinery of aging. Life Medicine, 2022, 1(2): 81-83 DOI:10.1093/lifemedi/lnac016

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References

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[1]	López-OtínC, BlascoMA, Partridge L, et al. The hallmarks of aging. Cell 2013;153:1194–217.

[2]	Lopez-OtinC, Kroemer G. Hallmarks of health. Cell 2021;184:33–63.

[3]	Hernandez-SeguraA, Nehme J, DemariaM. Hallmarks of cellular senescence. Trends Cell Biol 2018;28:436–53.

[4]	ZhangW, QuJ, LiuGH, et al. The ageing epigenome and its rejuvenation. Nat Rev Mol Cell Biol 2020;21:137–50.

[5]	ZabranskyDJ, JaffeeEM, WeeraratnaAT. Shared genetic and epigenetic changes link aging and cancer. Trends Cell Biol 2022;32:338–50.

[6]	SadaieM, SalamaR, CarrollT, et al. Redistribution of the LaminB1 genomic binding profile affects rearrangement of heterochromatic domains and SAHF formation during senescence. Genes Dev 2013;27:1800–08.

[7]	ScaffidiP, Misteli T. Lamin A-dependent misregulation of adult stem cells associated with accelerated ageing. Nat Cell Biol 2008;10:452–9.

[8]	ChandraT, EwelsPA, SchoenfelderS, et al. Global reorganization of the nuclear landscape in senescent cells. Cell Rep 2015;10:471–83.

[9]	LiuZ, JiQ, RenJ, et al. Large-scale chromatin reorganization reactivates placenta-specific genes that drive cellular aging. Dev Cell 2022;57:1–22.