Single-cell immune atlas for human aging and frailty

References

[1] HanX, ZhouZ, FeiL, et al. Construction of a human cell landscape at single-cell level. Nature 2020;581:303–309

[2] HeX, Memczak S, QuJ, et al. Single-cell omics in ageing: a young and growing field. Nat Metab 2020;2:293–302

[3] MogilenkoDA, Shchukina I, ArtyomovMN. Immune ageing at single- cell resolution. Nat Rev Immunol 2022;22:484–498

[4] Aging AtlasC. Aging Atlas: a multi-omics database for aging biology. Nucleic Acids Res 2021;49:D825–D830

[5] ChenX, MaoG, LengSX. Frailty syndrome: an overview. Clin Interv Aging 2014;9:433–441

[6] ChenY, LiuS, LengSX. Chronic low-grade inflammatory phenotype (CLIP) and senescent immune dysregulation. Clin Ther 2019;41:400–409

[7] ChenY, KleinSL, GaribaldiBT, et al. Aging in COVID-19: vulnerability, immunity and intervention. Ageing Res Rev 2021;65:101205

[8] LuoOJ, LeiW, ZhuG, et al. Multidimensional single-cell analysis of human peripheral blood reveals characteristic features of the immune system landscape in aging and frailty. Nat Aging 2022;2:348–364

[9] ZhengY, LiuX, LeW, et al. A human circulating immune cell landscape in aging and COVID-19. Protein Cell 2020;11:740–770

[10] HashimotoK, KounoT, IkawaT, et al. Single-cell transcriptomics reveals expansion of cytotoxic CD4 T cells in supercentenarians. Proc Natl Acad Sci USA 2019;116:24242–24251

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The Author(s) 2022. Published by Oxford University Press on behalf of Higher Education Press.