Counter changes with changelessness: cope with SARS-CoV-2 immune evasion by targeting cryptic epitopes

Cheng Li , Tianlei Ying , Dimiter S. Dimitrov , Yanling Wu

Life Medicine ›› 2022, Vol. 1 ›› Issue (1) : 24 -26.

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Life Medicine ›› 2022, Vol. 1 ›› Issue (1) : 24 -26. DOI: 10.1093/lifemedi/lnac006
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Counter changes with changelessness: cope with SARS-CoV-2 immune evasion by targeting cryptic epitopes

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Cheng Li, Tianlei Ying, Dimiter S. Dimitrov, Yanling Wu. Counter changes with changelessness: cope with SARS-CoV-2 immune evasion by targeting cryptic epitopes. Life Medicine, 2022, 1(1): 24-26 DOI:10.1093/lifemedi/lnac006

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References

[1]

Yu F, Song H, Wu Y, et al. A potent germline-like human monoclonal antibody targets a pH-sensitive epitope on H7N9 influenza hemagglutinin. Cell Host Microbe 2017;22:471–83.

[2]

Bangaru S, Lang S, Schotsaert M, et al. A site of vulnerability on the influenza virus hemagglutinin head domain trimer interface. Cell 2019;177:1136–52.

[3]

Watanabe A, McCarthy KR, Kuraoka M, et al. Antibodies to a conserved influenza head interface epitope protect by an IgG subtype-dependent mechanism. Cell 2019;177:1124–35.

[4]

Cao Y, Wang J, Jian F, et al. Omicron escapes the majority of existing SARS-CoV-2 neutralizing antibodies. Nature 2022;602:657–657.

[5]

Li C, Zhan W, Yang Z, et al. Broad neutralization of SARS-CoV-2 variants by an inhalable bispecific single-domain antibody. Cell 2022;185(8):1389–401.

[6]

Tian X, Li C, Huang A, et al. Potent binding of 2019 novel coronavirus spike protein by a SARS coronavirus-specific human monoclonal antibody. Emerg Microbes Infect 2020;9:382–5.

[7]

Yuan M, Wu NC, Zhu X, et al. A highly conserved cryptic epitope in the receptor binding domains of SARS-CoV-2 and SARS-CoV. Science 2020;368:630–3.

[8]

Starr TN, Czudnochowski N, Liu Z, et al. SARS-CoV-2 RBD anti-bodies that maximize breadth and resistance to escape. Nature 2021;597:97–102.

[9]

Starr TN, Greaney AJ, Hilton SK, et al. Deep mutational scanning of SARS-CoV-2 receptor binding domain reveals constraints on folding and ACE2 binding. Cell 2020;182:1295–310.

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