Regulatory role of CREB/BDNF signaling pathway in acute sleep deprivation-induced anxiety-like behavior mice

Abstract

Objective: To investigate the regulatory role of cyclic adenosine monophosphate responsive element binding protein (CREB)/brain-derived neurotrophic factor (BDNF) signaling pathway in acute sleep deprivation (SD)-induced anxiety-like behavior mice (SD group) to study the mechanism of anxiety-like behavior better. Methods: The SD chamber was used to deprive the mice of sleep, and the anxiety-like behavior of the mice was verified using an open field test (OFT), elevated plus maze (EPM), forced swim test (FST), and tail suspension test (TST). Finally, proteins were detected by Western blotting. Result: OFT showed that the active distance and the time of stay in the central area were significantly reduced (P<0.05). EPM showed that the time and number of open arms in the SD group were significantly lower than in the control group (P<0.05). The FST showed that the forced swimming immobility time of the SD group was significantly lower than that of the control (P<0.05). Moreover, the TST showed that the immobility time of the tail suspension experiment in the SD group was significantly higher than that in the control group (P<0.05). Conclusion: Acute SD can regulate anxiety-like behavior in mice through the CREB/BDNF signaling pathway.

Keywords

sleep deprivation / anxiety-like behavior / cyclic adenosine monophosphate responsive element binding protein (CREB) / brain-derived neurotrophic factor (BDNF) / signaling pathway