Progress and challenges of cerebrovascular endothelial cells research promoted by single-cell transcriptome sequencing technology

Abstract

Single-cell transcriptome sequencing has been a rapidly developing and powerful biological tool in recent years, and it plays a vital role in describing tissue development, cell heterogeneity, stress response, etc. Cerebrovascular disease is one of the leading causes affecting human health in the world. Thus, it is important to understand the characteristics of cerebrovascular structure, function, and environmental response. Notably, single-cell transcriptome sequencing provides deeper insights into cerebrovascular research in health and disease states. This article will briefly introduce the basic structure and function of cerebrovascular endothelial cells (ECs), summarize the current research and new findings on cerebrovascular ECs at the single-cell transcriptome level, and discuss the challenges in this field.

Keywords

blood-brain barrier / cerebrovascular endothelial cells / single-cell transcriptome sequencing / cerebrovascular diseases