The roles of BDNF and ProBDNF in schizophrenia: possi- bilities for treatment

Yuhang Liang, Tiantian Jiang, Yinhang Li, Hongying Pan, Min Mo

doi:10.3868/j.issn.2096-0689.2023.02.003

Journal of Translational Neuroscience ›› 2023, Vol. 8 ›› Issue (2) : 13 -17. DOI: 10.3868/j.issn.2096-0689.2023.02.003

Review

The roles of BDNF and ProBDNF in schizophrenia: possi- bilities for treatment

Yuhang Liang, Tiantian Jiang, Yinhang Li, Hongying Pan, Min Mo

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Abstract

This review discusses the roles of brain-derived neurotrophic factor (BDNF) and precursor BDNF (proBDNF) in schizophrenia (SCZ). SCZ is associated with neuronal dysfunction, altered synaptic plasticity, and cognitive deficits. BDNF positively promotes neuronal growth, differentiation, and synapse formation, and regulates synaptic transmission and plasticity. ProBDNF negatively affects neuronal survival and synaptic remodeling, however, by binding to its neurotrophin receptor p75 (p75NTR). A better understanding of the pathogenesis of SCZ vis-à-vis BDNF and proBDNF may provide new directions and strategies for its treatment.

Keywords

schizophrenia (SCZ) / brain-derived neurotrophic factor (BDNF) / precursor BDNF (ProBDNF)

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Yuhang Liang, Tiantian Jiang, Yinhang Li, Hongying Pan, Min Mo. The roles of BDNF and ProBDNF in schizophrenia: possi- bilities for treatment. Journal of Translational Neuroscience, 2023, 8(2): 13-17 DOI:10.3868/j.issn.2096-0689.2023.02.003