Research progress of hsa-miR-495-3p and proteolipid protein 1 involvement in the pathogenesis of schizophrenia

Abstract

Schizophrenia (SCZ) is a serious mental illness whose etiology and pathogenesis are not yet clear. The level of miRNA may be a crucial factor in the occurrence and development of SCZ. This study found that miR-495 may regulate the susceptibility gene of SCZ and that proteolipid protein 1 (PLP1) as a risk gene for schizophrenia may be involved in its pathogenesis. In this article we review the research progress related to hsa-miR-495-3p (miR-495), PLP1, and schizophrenia.

Keywords

schizophrenia (SCZ) / hsa-miR-495-3p (miR-495) / proteolipid protein 1 (PLP1)