Expression of yeast silencing information regulator 2 in secondary injury of intracerebral hemorrhage

Abstract

Objective: to investigate the expression of yeast silencing information regulator 2 (Sirt2) in the secondary injury of intracerebral hemorrhage (ICH). Methods: twelve Sprague Dawley (SD) rats were randomly divided into a sham group and an ICH group, with six rats in each group. A rat model of ICH was established by injecting collagenase type IV into the right striatum of the rats. The expression of Sirt2 was measured by Western blot and immunohistochemistry after ICH. Result: the behavioral score of the ICH rats was the lowest at 48 h after the operation; therefore the rats at 48 h after surgery were selected as the model rats. The expression of Sirt2 was significantly higher in the striatal tissue of the ICH rats compared with the sham group (P＜0.05). Conclusion: the expression of Sirt2 around hematoma in ICH rats decreases, and Sirt2 is expected to become a new target for ICH treatment.

Keywords

intracerebral hemorrhage (ICH) / secondary injury / silencing information regulator 2 (Sirt2)