Research progress of immunotherapies in malignant glioma

Abstract

Glioma is the most common and destructive tumor of primary brain tumor types in the central nervous system. After comprehensive treatment including surgical treatment, radiation therapy and chemical drug treatment, the survival period of the glioma patients is still very short. In recent years, cancer immunotherapy methods have achieved great success in the treatment of solid tumors, but the application in the treatment of gliomas has not been universal yet. This review discussed the immunotherapy and latest progress in glioma study, hoping to bring new ideas for treatment of gliomas.

Keywords

glioma / immune checkpoint inhibitor / chimeric antigen receptor T cell (CAR-T) therapy / dendritic cells / immunotherapy