Translation of basic science into clinical medicine in management for neurogenic bladder

Abstract

Neurogenic bladder (NB) dysfunction caused by spinal cord injury (SCI) or diseases of the central nervous system or peripheral nerves is a major medical and social problem. Traditional treatments to NB include medication, injection of Botulinum toxin A into the detrusor, neuromodulation and surgery. There are also emerging approaches, such as tissue engineering, stem cell transplantation and gene therapy. In recent years, we have carried out explorations in both therapeutic areas and tried to translate basic research into clinical practice. This paper reviews our work in this regard, and provides references for future research.

Keywords

neurogenic bladder (NB) / medication / urinary tract reconstruction / neuromodulation / stem cell transplantion / gene therapy