Protective effect of Solanum Nigrum Linn green fruit ethanolic extract on alcoholic liver injury in mice

Abstract

Alcoholic liver injury is a liver disease caused by excessive alcohol consumption, which can lead to chronic liver disease death. Solanum Nigrum Linn taste bitter, cold, has the effect of clearing heat and detoxification, promoting blood and detumescence. Solanum Nigrum Linn fruit contains a variety of antioxidant enzymes, can remove the body produced by aerobic metabolism harmful substances. In this paper, a model of alcohol-induced liver injury in C57BL/6 mice was established to evaluate the protective effect of Solanum Nigrum Linn green fruit (SNGF) ethanolic extract on alcohol-induced liver injury. H&E staining and oil red O (ORO) staining showed that hepatic lobules were clearly demarcated, vacuoles were significantly reduced and lipid droplets were reduced in SNGF ethanolic extract treatment group. Serum levels of TC, TG, LDH, TBA, AKP, ALT and AST were decreased in the SNGF ethanolic extract treatment group, and SNGF ethanolic extract could clear reactive oxygen species (ROS) in time. MDA content was significantly decreased after SNGF ethanolic extract treatment, while superoxide dismutase (SOD) and GSH-Px contents were increased after SNGF ethanolic extract treatment. These results suggest that SNGF ethanolic extract has a protective effect on alcohol-induced liver injury.

Keywords

Solanum Nigrum Linn green fruit ethanolic extract / alcoholic liver injury / protective effect

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