Vitexin is a natural phytoflavonoid glycoside extracted from the leaves of vitexin, a plant of the Verbenaceae family, which is an active ingredient in many traditional Chinese medicines and is present in a wide range of medicinal plants. In this review, pharmacological effects including anti-inflammatory, diabetes mellitus are described. The novel formulation of vitexin of nano delivery and hybrid micelles are elucidated.

Genistein phospholipid complex (GS-PC) was produced in order to increase the solubility and antioxidant activity of genistein (GS), an insoluble natural polyphenol compound. By using the solvent evaporation process, GS-PC was produced. Several characteristics techniques were used to confirm the production of GS-PC, and its physicochemical characteristics and antioxidant activity were investigated. The outcome showed that GS-PC had a recombination rate of 96.84% ± 0.51%. The characterization results confirmed that GS-PC was formed by the intermolecular interaction between GS and phospholipids. In vitro antioxidant studies showed that GS-PC had a certain scavenging ability on DPPH free radicals, ABTS free radicals and hydroxyl free radicals. In summary, the results of this study indicated that GS-PC could be used as a formula to improve its solubility and antioxidant activity.

Liver fibrosis is the formation of extracellular matrix deposits due to excessive repair of chronic liver damage. Liver fibrosis is a necessary stage in the progression of cirrhosis, and timely intervention reverses the pathogenesis. Liver fibrosis is a dynamic and highly integrated molecular, cellular and organisational process. Currently, no specific drug is used to treat liver fibrosis, and liver transplantation is the main clinical treatment for cirrhosis. Chemical drugs are often designed to target individual genes or proteins, with kinds of side effects. Food polyphenols, which are available and safe, have unique advantages and great potential in the treatment with the liver fibrosis. This review summarizes the pathogenesis of liver fibrosis and provides examples of food polyphenols’ anti-liver fibrosis mechanisms that have been identified in recent studies, and provides some sights for the development of anti-liver fibrosis drugs.

Evidence of the advantages of Solanum nigrum L. for the treatment of ulcerative colitis is accumulating. However, research revealing the treatment of Solanum diphyllum L. against ulcerative colitis is scarce. In this study, the chemical components of the extract of Solanum diphyllum L. were characterized by LC-MS/MS, identifying 31 compounds by positive and negative total ion flow maps. A total of 425 component target genes and 1 900 disease target genes were obtained, and 121 intersection targets and 6 core targets were obtained after the intersection of the two genes by means of network pharmacology. GO analysis and KEGG analysis respectively obtained 20 signaling pathways such as anti-inflammation. The results of molecular docking showed that the chemical components could successfully dock with the target proteins of the disease such as SRC, EGFR, PTGS2, MMP9, HSP90AA1, ESR1. This study provided a scientific basis for the development and application of Solanum diphyllum L.