Water-soluble A-D-A Fluorescent Probes with Large Stokes Shift for Hypochlorite Detection

Abstract

Two novel water-soluble A-D-A fluorescent probes (H01 and H02), composed of a phenol moiety that functions as a latent donor in conjugation with two picoliniums, were designed and synthesized for selective detection of hypochlorite. Both probes show rapid response to hypochlorite and a favorable linear correlation between hypochlorite concentration and fluorescent intensity. And the detection limit is calculated as 3.39 µM for H01 and 4.95 µM for H02, respectively. These probes also exhibit high selectivity, rapid response (3 s) and large Stokes shift. Both exhibit good biocompatibility, allowing effective monitoring of the exogenous hypochlorite fluctuations in living cells.

Keywords

water-soluble / A-D-A / probe / hypochlorite / large stokes shift

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