Enzyme-powered Janus nanomotors using SiO2 as carriers have demonstrated significant application potentials in the field of biomedicine, attributed to their autonomous motility and excellent biocompatibility. This article constructs two urease-powered Janus nanomotors (Ur-JNDSNPs and Ur-JNMSNPs) based on different SiO2 structures, namely dendritic mesoporous and non-dendritic mesoporous, and studies the effect of carrier structure on the fabrication of nanomotors and their motion behaviors in biological medium. The results show that, in comparison to Ur-JNMSNPs, the nanomotors constructed based on dendritic mesoporous (Ur-JNDSNPs) exhibit superior mobility in both water and PBS solution as a simulated body fluid. Notably, they show excellent colloid stability and protein-resistant mobility, which enables substantially higher mobility in DMEM medium containing proteins compared to in PBS solution. This characteristic confers them with penetration ability in simulated physiological environments. This finding stands in stark contrast to most previously reported nanomotors and underscores the importance of rationally designing carrier structures to advance the biomedical applications of nanomotors.
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