Liposome@IR780 Nanoparticles for Efficient Sonodynamic Therapy to Treat Triple-negative Breast Cancer

Abstract

The hydrophobic sonosensitizer IR780 iodide (IR780) was loaded into liposomes to form Liposome@IR780 nanoparticles (NPs) for triple-negative breast cancer (TNBC) to enhance SDT via low-intensity ultrasound (LIU) irradiation. The NPs were characterized using various physicochemical methods including size distribution, zeta potential, and morphology. In vitro experiments show that the Liposome@IR780 NPs can generate more reactive oxygen species (ROS) upon LIU irradiation. The apoptosis experiment results further demonstrate that Liposome@IR780 NPs show better apoptosis rate against 4T1 cells. Our results indicate that Liposome@IR780 NPs will provide a promising approach for TNBC upon SDT treatment.

Keywords

IR780 / Liposome@IR780 NPs / sonodynamic therapy / triple-negative breast cancer

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Wuhan University of Technology and Springer-Verlag GmbH Germany, Part of Springer Nature