Fabrication of Porous Polycaprolactone/Carboxymethylcellulose Scaffolds by using Salt Leaching Technique

Abstract

The purpose of this work was to fabricate three-dimensional porous scaffolds by using the salt leaching technique. This technique is simple and it does not need the pressure or dislike expensive equipment. The study selected polycaprolactone blended with carboxymethylcellulose that is the additive. The ratios of them were derived from mixture design in Minitab program that was 98/2(P1), 93.5/6.5(P2), 89/11(P3), 84.5/15.5(P4), and 80/20(P5), respectively. The scanning electron microscopy (SEM) was applied to assess the physical properties and the pore size dimension of the scaffold from SEM micrographs. The results of SEM present the scaffolds happened interconnected porous structures that are found in all of the P1–P5 samples. The pore size dimension of all sample scaffolds is in the range of 264.11–348.28 µm. Whereas the largest and the smallest of pore size are the sample of P3 and P2, respectively, while the porosity ranges from 98.06%–98.88% that the sample of P5 is the greatest and the sample of P4 is the slightly lowest. In conclusion, the blended PCL/CMC scaffolds P1–P5 were formed by salt leaching technique suitable to use in tissue engineering application. However, the amount of CMC blended with PCL should be reasonable in order to adjust the hydrophilic of the scaffold.

Keywords

polycaprolactone (PCL) / carboxymethylcellulose (CMC) / salt leaching / tissue engineering / scaffolds

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