Fabrication and Characterization of Poly Lactic Acid Scaffolds by Fused Deposition Modeling for Bone Tissue Engineering

Abstract

Three-dimensional porous poly-lactic acid (PLA) scaffold was fabricated using fused deposition modeling (FDM) method including 30%, 50% and 70% nominal porosity. Study of phases in initial polymeric material and printed scaffolds was done by X-ray diffraction (XRD), and no significant phase difference was observed due to the manufacturing process, and the poly-lactic acid retains its crystalline properties. The results of the mechanical properties evaluation by the compression test show that the mechanical properties of the scaffold have decreased signifcantly with increasing the porosity of scaffold. The microstructure of scaffolds were studied by scanning electron microscope (SEM), showing that the pores had a regular arrangement and their morphology changed with porosity change. The mechanical properties of the poly-lactic acid scaffolds printed using fused deposition modeling, can be adapted to the surrounding tissue, by porosity change.

Keywords

3D porous scaffold / fused deposition modeling / poly-lactic acid / biodegradable polymer