Fabrication and Characterization of Poly Lactic Acid Scaffolds by Fused Deposition Modeling for Bone Tissue Engineering

Abstract

Three-dimensional porous poly-lactic acid (PLA) scaffold was fabricated using fused deposition modeling (FDM) method including 30%, 50% and 70% nominal porosity. Study of phases in initial polymeric material and printed scaffolds was done by X-ray diffraction (XRD), and no significant phase difference was observed due to the manufacturing process, and the poly-lactic acid retains its crystalline properties. The results of the mechanical properties evaluation by the compression test show that the mechanical properties of the scaffold have decreased signifcantly with increasing the porosity of scaffold. The microstructure of scaffolds were studied by scanning electron microscope (SEM), showing that the pores had a regular arrangement and their morphology changed with porosity change. The mechanical properties of the poly-lactic acid scaffolds printed using fused deposition modeling, can be adapted to the surrounding tissue, by porosity change.

Keywords

3D porous scaffold / fused deposition modeling / poly-lactic acid / biodegradable polymer

References

[1] Khodaei M, Meratian M, Savabi O, et al. The Effect of Sintering Temperature on the Properties of Porous Titanium Implant Manufactured by Space Holder Method[J]. Journal Advanced Processes in Materials Engineering, 2015, 9(3): 1-9.

[2] Hosseini S, Sadrnezhaad S K, Ekrami Aliakbar. Phase Transformation Behavior of Porous NiTi Alloy Fabricated by Powder Metallurgical Method[J]. Materials Science and Engineering C, 2009, 29(7): 2 203-2 207.

[3] Corcione C E, Gervaso F, Scalera F, et al. Highly Loaded Hydroxyapatite Microsphere/ PLA Porous Scaffolds Obtained by Fused Deposition Modelling[J]. Ceramics International, 2019, 45(2): 2 803-2 810.

[4] Lin W, Shen H, Xu G, et al. Single-layer Temperature-adjusting Transition Method to Improve the Bond Strength of 3D-printed PCL/PLA Parts[J]. Composites Part A, 2018, 115: 22-30.

[5] Kun Krisztián. Reconstruction and Development of a 3D Printer Using FDM Technology[J]. Procedia Engineering, 2016, 149: 203-211.

[6] Rinaldi M, Ghidini T, Cecchini F, et al. Additive Layer Manufacturing of poly (Ether Ether Ketone) via FDM[J]. Composites Part B, 2018, 145(15): 162-172.

[7] Gomez-Gras G, Jerez-Mesa R, Travieso-Rodriguez J, et al. Fatigue Performance of Fused Filament Fabrication PLA Specimens[J]. Materials & Design, 2018, 140(15): 278-285.

[8] Wang H, Zhi W, Lu X, et al. Comparative Studies on Ectopic Bone Formation in Porous HA Scaffolds with Complementary Pore Structures[J]. Acta Biomaterialia, 2013, 9(9): 8 412-8 413.

[9] Tan L, Yu X, Wan P, et al. Biodegradable Materials for Bone Repairs: A Review[J]. J. Mater. Sci. Technol., 2013, 29(6): 503-513.

[10] Bhatia S K. Biomaterials for Clinical Applications[M], 2010 New York: Springer.

[11] Ostrum Robert F. Biomechanics in Orthopedic Trauma. Bone Fracture and Fixation[J]. The Journal of Bone and Joint Surgery, 1994, 76(9): 1 438-1 438.

[12] Wieding J, Wolf A, Bader Rainer. Numerical Optimization of Open-Porous Bone Scaffold Structures to Match the Elastic Properties of Human Cortical Bone[J]. Journal of Mechanical Behavior of Biomedical Material, 2014, 37: 56-68.

[13] Mohseni K H, Sanamiri K, Hashemitabar Mahmoud. Application of Alginate Capsules as a Three Dimensional Scaffold for Differentiation of Wharton’s Jelly Mesenchymal Stem Cells to Definitive Endoderm[J]. Arak Medical University Journal, 2014, 17(85): 54-66.

[14] Wan L, Zhang Yanhua. Jointly Modifed Mechanical Properties and Accelerated Hydrolytic Degradation of PLA by Interface Reinforcement of PLA-WF[J]. Journal of the Mechanical Behavior of Biomedical Materials, 2018, 88: 223-230.

[15] Simmons H, Kontopoulou Marianna. Hydrolytic Degradation of Branched PLA Produced by Reactive Extrusion[J]. Polymer Degradation and Stability, 2018, 158: 228-237.