Preparation and Evaluation of Dual Targeting Nanoparticles for Oral Cancer

Shanshan Wu; Fuliang Xiong; Xueqiong Zhang; Tong Qiu; Mingxiu Tang; Xiaojing Ye; Zhijun Chen; Gang Zhou

doi:10.1007/s11595-019-2218-4

Journal of Wuhan University of Technology Materials Science Edition ›› 2020, Vol. 34 ›› Issue (6) : 1495 -1504. DOI: 10.1007/s11595-019-2218-4

Biomaterial

Preparation and Evaluation of Dual Targeting Nanoparticles for Oral Cancer

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Abstract

A dual-receptor targeting delivery system based on acid-cleavage hydrazone bond was developed in the study. The characters of CMCS-hyd-CUR-EGFR- mAb were identifed. The in vitro release studies revealed that this drug delivery system was acid-sensitive, and the self-assembled nanoparticles which were spherical. The in vitro results indicated that the dual-receptor targeting nanoparticles could be faster internalized into the Cal-27 cells via receptor-mediated endocytosis, which exhibited better antitumor activity than the one-receptor nanoparticles. The experimental results clearly reveal that CMCS-hyd-CUR-EGFR mAb provides a novel way for drug delivery in oral cancer treatment.

Keywords

hydrazone bond / dual-receptor targeting / self-assembly / nanoparticle

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Shanshan Wu, Fuliang Xiong, Xueqiong Zhang, Tong Qiu, Mingxiu Tang, Xiaojing Ye, Zhijun Chen, Gang Zhou. Preparation and Evaluation of Dual Targeting Nanoparticles for Oral Cancer. Journal of Wuhan University of Technology Materials Science Edition, 2020, 34(6): 1495-1504 DOI:10.1007/s11595-019-2218-4