Structural and regulating characteristics of adjustable annulus-clearance nozzle used in supercritical fluid precipitation

Abstract

A new type of adjustable nozzle with an annulus clearance between the surfaces of a revolved solid and the matched hole was analyzed, which contained matching parts, regulating parts, guiding elements, and sealing part. The general regulating function of the adjustable nozzle was derived and the regulating and matching characteristics were also analyzed. Through the analysis, it was concluded that the matching-profile curve of either the revolved body or matched hole should be chosen as a straight line in order to keep the linear regulating feature. Moreover, the multi-annulus-clearance nozzle was designed, and some experiments were carried out on preparing budesonide particles with the nozzle. According to the experimental results, it was proved that the annulus nozzles is practical in preparing micro-particles by supercritical fluid precipitation method.

Keywords

annulus-clearance nozzle / adjustable structure / regulating characteristics / conic matching / supercritical fluid precipitation

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