Effects of calcination temperature of boron-containing magnesium oxide raw materials on properties of magnesium phosphate cement as a biomaterial

Abstract

A new magnesium phosphate bone cement (MPBC) was prepared as a byproduct of boroncontaining magnesium oxide (B-MgO) after extracting Li₂CO₃ from salt lakes. We analyzed the elementary composition of the B-MgO raw materials and the effects of calcination temperature on the performance of MPBC. The phase composition and microstructure of the B-MgO raw materials and the hydration products (KMgPO₄·6H₂O) of MPBC were analyzed by X-ray diffraction and scanning electron microscopy. The results showed that ionic impurities and the levels of toxic elements were sufficiently low in B-MgO raw materials to meet the medical requirements for MgO (Chinese Pharmacopeia, 2010 Edition) and for hydroxyapatite surgical implants (GB23101.1-2008). The temperature of B-MgO calcination had a marked influence on the hydration and hardening of MPBC pastes. Increasing calcination temperature prolonged the time required for the MPBC slurry to set, significantly decreased the hydration temperature, and prolonged the time required to reach the highest hydration temperature. However, the compressive strength of hardened MPBC did not increase with higher calcination temperatures. In the 900-1 000 °C temperature range, the hardened MPBC had a higher compressive strength. Imaging analysis suggested that the setting time and the highest hydration temperature of MPBC pastes were dependent on the size and crystal morphology of the B-MgO materials. The production and microstructure compactness of KMgPO₄·6H₂O, the main hydration product, determined the compressive strength.

Keywords

magnesium phosphate bone cement / boron-containing magnesium oxide / calcination temperature

References

[1] Yang Q B, Wu X. Factors Influencing Properties of Phosphate Cement-Based Binder for Rapid Repair of Concrete[J]. Cement and Concrete Research, 1999, 29(3): 389-396.

[2] Yang Q B, Zhu B, Wu X. Characteristics and Durability Test of Magnesium Phosphate Cement-Based Material for Rapid Repair of Concrete[J]. Materials and Structures, 2000, 33(4): 229-234.

[3] Yang Q B, Zhang S, Wu X. Deicer-Scaling Resistance of Phosphate Cement-Based Binder for Rapid Repair of Concrete[J]. Cement and Concrete Research, 2002, 32(1): 165-168.

[4] Arun S W, Seung Y Jeong. Chemically Bonded Phosphate Ceramics: I, A Dissolution Modle of Formation[J]. J. Am. Ceram. Soc., 2003, 86(11): 1838-1844.

[5] Jiang Q Y, Zhang L M. Research of Magnesium Phosphate Cement[J]. Journal of Wuhan University of Technology -Materials Science Edition, 2011, 23(1): 32-34.

[6] Moseke C, Saratsis V, Gbureck U. Injectability and Mechanical Properties of Magnesium Phosphate Cements[J]. J. Mater. Sci. Mater. Med., 2011, 22: 2591-2598.

[7] Wang A, Yuan Z, Zhang J, et al. Effect of Raw Material Ratios on the Compressive Strength of Magnesium Potassium Phosphate Chemically Bonded Ceramics[J]. Mater. Sci. Eng. C, 2013, 33: 5058-5063.

[8] Mestres G, Ginebra MP. Novel Magnesium Phosphate Cements with High Early Strength and Antibacterial Properties[J]. Acta Biomater., 2011, 7: 1853-1861.

[9] Gulotta LV, Kovacevic D, Ying L, et al. Augmentation of Tendon-to-Bone Healing with a Magnesium-Based Bone Adhesive[J]. Am. J. Sports Med., 2008, 36: 1290-1297.

[10] Waselau M, Samii VE, Weisbrode SE, et al. Effects of a Magnesium Adhesive Cement on Bone Stability and Healing Following a Metatarsal Osteotomy in Horses[J]. Am. J. Vet. Res., 2007, 68: 370-378.

[11] Wu F, Wei J, Guo H, et al. Self-Setting Bioactive Calcium-Magnesium Phosphate Cement with High Strength and Degradability for Bone Regeneration[J]. Acta Biomater., 2008, 4: 1873-1884.

[12] Eubank WR. Calcination Studies of Magnesium Oxides[J]. J. Am. Ceram. Soc., 1951, 34: 225-229.

[13] Soudée E, Péra J. Influence of Magnesia Surface on the Setting Time of Magnesia-Phosphate Cement[J]. Cement Concrete Res., 2002, 32: 153-157.

[14] Fang H S, Zhao H C, Zhang X D. Implants for Surgery-Hydroxyapatite-Part 1: Ceramic Hydroxyapatite[S], 2009

[15] Bruker. Bruker AXS (2006)[M], 2006 Karlsruhe: TOPAS Bruker AXS Inc.

[16] State Pharmacopoeia Commission. Pharmacopoeia of the People’s Republic of China-Part 2: Magnesium Oxide[M], 2010 Beijing: Chinese Medical Science and Technology Press.