Synthesis and bio-activities of poly (3,4-ethylenedioxythiophene) (PEDOT)/poly (styrene sulfonate) (PSS)/gelatin layer on indium tin oxide (ITO)-coated glass

Abstract

Poly (3, 4-ethylenedioxythiophene) (PEDOT), together with its dopes, such as poly (styrene sulfonate) (PSS), has been acknowledged to have a wide range of biomedical applications as an important conducting polymer. In this study, gelatin can be polymerized into PEDOT/PSS polymers on indium tin oxide (ITO)-coated glass. PEDOT/PSS/gelatin layer on ITO-coated glass significantly decreases electrochemical impedance spectroscopy (EIS) and increases charge delivery capacity relative to the gelatin layer and bare ITO-coated glass, comparable to the PEDOT/PSS layer on ITO-coated glass. PEDOT/PSS/gelatin layer on ITO-coated glass enhances pheochromocytoma (PC 12) cell affinity, possesses a high biocompatibility and promotes PC 12 cell growth by delivery of electrical stimulation. These results suggest that gelatin can be incorporated into the PEDOT/PSS polymers through electrochemical polymerization and the PEDOT/PSS/gelatin layer on ITO-coated glass possesses high electrochemical and biological activities.

Keywords

poly (3,4-ethylenedioxythiophene) (PEDOT) / gelatin / electrochemistry / electrical stimulation / PC 12 cell

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