Mesoporous bioglass/silk fibroin scaffolds as a drug delivery system: Fabrication, drug loading and release in vitro and repair calvarial defects in vivo

Abstract

The potential of combining bioactive glass(MBG) and silk fibroin(SF) together as a new drug delivery system was evaluated. The three-dimensional porous scaffolds were selected as the form of SF, and sol-gel method was adopted to fabricate MBG in this study. The characteristic of the synthesized material was measured by transmission electron microscopy and scanning electron microscopy. In vitro evaluation of drug delivery was carried out in terms of drug loading and drug release. And aspirin was chosen as the drug for scaffolds to carry out in vitro tests and repair BALB/C mice calvarial defects. Bone formation was examined by microcomputed tomography. The experimental results show that MBG/silk scaffolds have better physiochemical properties compared with silk scaffolds. In comparison to pure silk scaffolds, MBG/silk scaffolds enhance the drug loading efficiency, release rate in vitro and promote bone regeneration in vivo. Thus we conclude that MBG/silk scaffold is a more efficient drug delivery system than pure silk scaffolds.

Keywords

silk fibroin / mesoporous bioactive glass / drug delivery / calvarial defect / aspirin

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