Preparation of PLGA ceftiofur hydrochlorate lungtargeted microsphere with spray drying process

Abstract

To explore the preparation of PLGA ceftiofur hydrochlorate lung-targeted microsphere with spray drying process, the preparation technics was optimized by orthogonal experiments. Appearance, particle size, drug-loaded properties and medicine dissolution rate of the microsphere were evaluated. The experimental results show that the prepared PLGA microspheres loaded with ceftiofur hydrochlorate have good appearance, good encapsulate rate and dissolution. The drug loading capacity of ceftiofur-hydrochlorate-loaded PLGA microsphere prepared with spray drying process is 23.06%, i e, when the dosing ratio is 1:3, the encapsulate rate is 92.23% at maximum, and the release percentage of medicine is at 0.5 h. The medicine is released almost completely at 20 h and the accumulated medicine release is 98.12%.

Keywords

PLGA ceftiofur hydrochlorate microsphere / lung targeting / microsphere morphology

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