Preparation and drug-release behavior of β-TCP ceramics drug carrier in vitro

Qihuan Zhang; Xin Yan; Yuhua Yan; Honglian Dai; Xin Jiang; Shipu Li

doi:10.1007/s11595-012-0600-6

Journal of Wuhan University of Technology Materials Science Edition ›› 2012, Vol. 27 ›› Issue (6) : 1058 -1060. DOI: 10.1007/s11595-012-0600-6

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Preparation and drug-release behavior of β-TCP ceramics drug carrier in vitro

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Abstract

β-TCP ceramics drug carrier was first prepared and characterized. SEM showed that β-TCP carrier was in porous amorphous structure with diameters around 10 μm. The physical properties including apparent porosity, volume-weight, tensile strength and the permeability were measured and the results indicated those properties fit the clinical usage of β-TCP drug carrier. Furthermore, drug release experiment in vitro showed that the carrier could prolong drug release in simulated body fluid which provides basis for the clinical use of β-TCP ceramics as drug carrier.

Keywords

β-TCP ceramics / drug carrier / physicochemical properties / drug release / clinical use

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Qihuan Zhang, Xin Yan, Yuhua Yan, Honglian Dai, Xin Jiang, Shipu Li. Preparation and drug-release behavior of β-TCP ceramics drug carrier in vitro. Journal of Wuhan University of Technology Materials Science Edition, 2012, 27(6): 1058-1060 DOI:10.1007/s11595-012-0600-6

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