3D PLLA/nano-hydroxyapatite scaffolds with hierarchical porous structure fabricated by low-temperature deposition manufacturing

Yingchun Liang; Xiongfei Zheng; Wenjie Zhai; Tao Sun

doi:10.1007/s11595-012-0450-2

Journal of Wuhan University of Technology Materials Science Edition ›› 2012, Vol. 27 ›› Issue (2) : 265 -269. DOI: 10.1007/s11595-012-0450-2

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3D PLLA/nano-hydroxyapatite scaffolds with hierarchical porous structure fabricated by low-temperature deposition manufacturing

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Abstract

A new Precision Extrusion nozzle based ball screw transmission was developed. 3D hierarchical porous PLLA/nano-Hydroxyapatite(PLLA/nHA) scaffolds were fabricated by low-temperature deposition manufacturing. Scaffolds with macropores of 200–500 μm and micropores about 10 μm were fabricated through a thorough study and control of the processing parameters, in which the processing path and speed of material extrusion determine the macropores and there is a suitable temperature zone for fabricating qualified macropores. Micropore morphology can be controlled by adjusting supercooling of solvent crystallization or adding water into the solvent system. The compressive modulus of the scaffolds in air and phosphate buffer solution was measured, which increased with HA addition. In-vitro cell culture results showed a good biocompatibility of PLLA/HA scaffolds with the pre-osteoblastic MC3T3-E1 cells.

Keywords

tissue engineering / rapid prototyping / low-temperature deposition / scaffold / PLLA / nanohydroxyapatite

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Yingchun Liang, Xiongfei Zheng, Wenjie Zhai, Tao Sun. 3D PLLA/nano-hydroxyapatite scaffolds with hierarchical porous structure fabricated by low-temperature deposition manufacturing. Journal of Wuhan University of Technology Materials Science Edition, 2012, 27(2): 265-269 DOI:10.1007/s11595-012-0450-2

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