Effects of processing variables on the morphology and diameter of electrospun poly(amino acid ester)phosphazene nanofibers

Abstract

Poly[(alanino ethyl ester)_0.67 (glycino ethyl ester)_0.33 phosphazene (PAGP) was synthesized, and morphology and diameter of the electrospun PAGP nanofibers were systematically evaluated by using a cool field emission scanning electron microscope (SEM) with changing the important processing variables such as applied voltage, polymeric concentration, and ambient temperature. The average diameter of PAGP nanofibers was inversely proportional to the applied voltage, but increased with the increase of solution concentration. Lower environmental temperature was unfavorable due to the nanofibers conglutination.

Keywords

electrospinning / morphology / poly (amino acid ester)phosphazene / nanofibers

References

[1] Lannutti J., Reneker D., Ma T. e. a1. Electrospinning for Tissue Engineering Scaffolds[J]. Mater. Sci. and Eng. C, 2007, 27(3): 504-509.

[2] Liang D.H., Hsiao B.S., Chu B.J. Functional Electrospun Nanofibrous Scaffolds for Biomedical Applications[J]. Adv. Drug Delivery Rev., 2007, 59(14): 1 392-1 412.

[3] You Y., Min B.M., Lee S. e. a1. In Vitro Degradation Behavior of Electrospun Polyglycolide, Polylactide, and Poly (lactide-coglycolide)[ J]. J. Appl. Polym. Sci., 2005, 95(2): 193-200.

[4] Li M.Y., Mondrinos M.J., Gandhi M. e. a1. Electrospun Protein Fibers as Matrices for Tissue Engineering[J]. Biomaterials, 2005, 26(30): 5 999-6 008.

[5] Geng X.Y., Kwon O.H., Jang J.H. Electrospinning of Chitosan Dissolved in Concentrated Acetic Acid Solution[J]. Biomaterials, 2005, 26(27): 5 427-5 432.

[6] Smith L.A., Ma P.X. Nano-Fibrous Scaffolds for Tissue Engineering[J]. Colloid. and Surf. B:Biointerfaces, 2004, 39(3): 125-131.

[7] Sill T.J., Recum H.A.V. Electrospinning: Applications in Drug Delivery and Tissue Engineering[J]. Biomaterials, 2008, 29(13): 1 989-2 006.

[8] Buchko C.J., Chen L.C., Shen Y. e. a1. Processing and Microstructural Characterization of Porous Biocompatible Protein Polymer Thin Films[J]. Polymer, 1999, 40(26): 7 397-7 407.

[9] Deitzel J.M., Kleinmeyer J., Harris D. e. a1. The Effect of Processing Variables on the Morphology of Electrospun Nanofibers and Textiles[J]. Polymer, 2001, 42(1): 261-272.

[10] Tuteja A., Choi W., Ma M. e. a1. Designing Superoleophobic Surfaces[J]. Science, 2007, 318(5856): 1 618-1 622.

[11] Kumbar S.G., Nukavarapu S.P., James R. e. a1. Electrospun Poly (lactic acid-co-glycolic acid) Scaffolds for Skin Tissue Engineering[J]. Biomaterials, 2008, 29(30): 4100-4107.

[12] Mo X.M., Xu C.Y., Kotaki M. e. a1. Electrospun P(LLA-CL) Nanofiber: a Biomimetic Extracellular Matrix for Smooth Muscle Cell and Endothelial Cell Proliferation[J]. Biomaterials, 2004, 25(10): 1 883-1 890.

[13] Demir M.M., Yilgor I., Yilgor E. e. a1. Electrospinning of Polyurethane Fibers[J]. Polymer, 2002, 43(11): 3303-3309.

[14] Jaeger R., Schonherr H., Vancso G.J. Chain Packing in Electro-Spun Poly (ethylene oxide) Visualized by Atomic Force Microscopy[J]. Macromolecules, 1996, 29(23): 7 634-7 636.

[15] Allcock H.R., Steely L.B., Singh A. Hydrophobic and Superhydrophobic Surfaces from Polyphosphazenes[J]. Polym. Int., 2006, 55(6): 621-625.

[16] Singh A., Krogman N.R., Sethuraman S., . Effect of Side Group Chemistry on the Properties of Biodegradable L-Alanine Cosubstituted Polyphosphazenes[J]. Biomacromolecules, 2006, 7(3): 914-918.

[17] Sethuraman S., Nair L.S., Amin S.E., . In Vivo Biodegradability and Biocompatibility Evaluation of Novel Alanine Ester based Polyphosphazenes in a Rat Model[J]. J. Biomed. Mater. Res. Part A, 2006, 77A(4): 679-687.

[18] Carampin P., Conconi M.T., Lora S., . Electrospun Polyphosphazene Nanofibers for in Vitro Rat Endothelial Cells Proliferation[J]. J. Biomed. Mater. Res. Part A, 2007, 80A(3): 661-668.

[19] Nair L.S., Bhattacharyya S., Bender J.D., . Fabrication and Optimization of Methyl -phenoxy Substituted Polyphosphazene Nanofibers for Biomedical Applications[J]. Biomacromolecules, 2004, 5(6): 2 212-2 220.

[20] Zhang T., Hong T., Wu Z.P., . Study on the Relationship Between Structure and Properties of Poly[(amino acid ester)phosphazene] (1): Synthesis and Characterization[J]. Poly. Mat. Sci. Eng., 2006, 22(6): 90-94.

[21] Solomon O.F., Ciuta I.Z. Détermination de la Viscosité Intrinsèque de Solutions de Polymères par une Simple Détermination de la Viscosité[J]. J. Appl. Polym. Sci., 1962, 6(24): 683-686.

[22] Sulkowski W., Makarucha B., Sulkowska A., . Synthesis and Spectroscopic Studies of Cyclo- and Polyphosphazenes[J]. European Polymer Journal, 2000, 36(7): 1 519-1 524.

[23] Fong H., Reneker D.H., Chun I. Beaded Nanofibers Formed during Electrospinning[J]. Polymer, 1999, 40(16): 4 585-4 592.

[24] Fong H., Reneker D.H. Elastomeric Nanofibers of Styrene-Butadiene-Styrene Triblock Copolymer[J]. J. Polym. Sci: Part B: Polym. Phys., 1999, 37(24): 3 488-3 493.

[25] Megelski S., Stephens J.S., Chase D.B., . Micro- and Nanostructured Surface Morphology on Electrospun Polymer Fibers[J]. Macromolecules, 2002, 35(22): 8456-8466.

[26] Reneker D.H., Yarin A.L., Fong H., . Bending Instability of Electrically Charged Liquid Jets of Polymer Solutions in Electrospinning[J]. Joural of Applied Physics, 2000, 87(9): 4 531-4 537.

[27] Huang Z.M., Zhang Y.Z., Kotaki M., . A Review on Polymer Nanofibers by Electrospinning and Their Applications in Nanocomposites[J]. Composites Science and Technology, 2003, 63(15): 2 223-2 253.