Preparation and properties of gelatin-chitosan/montmorillonite drug-loaded microspheres

Abstract

A kind of slow release drug-loaded microspheres were prepared with gelatin, chitosan and montmorillonite(MMT) by an emulsification/chemical cross-linking method using glutaraldehyde as crosslinking agent and acyclovir as model drug. The microspheres were characterized by X-ray diffraction (XRD), Fourier transform infrared (FT-IR) and scanning electron microscopy (SEM), respectively. The morphology, drug content, encapsulation efficiency and drug-release behavior were investigated with different MMT contents. The experimental results indicated that intercalated microspheres could be prepared, the morphology of microspheres was markedly affected by MMT. The glomeration performance of uncross-linked microspheres was improved because of the physical cross-linking of MMT. Drug content and encapsulation efficiency were decreased when increased the content of MMT, but burst release and the drug release were signifi cantly decreased with the addition of MMT. Effective physical cross-linking could be formed when added MMT, and MMT could reduce the content of toxic chemical cross-linking agents.

Keywords

montmorillonite / gelatin / chitosan / microspheres / drug release

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