Antibacterial activity of silicate bioceramics

Abstract

Four kinds of pure silicate ceramic particles, CaSiO₃, Ca₃SiO₅, bredigite and akermanite were prepared and their bactericidal effects were systematically investigated. The phase compositions of these silicate ceramics were characterized by XRD. The ionic concentration measurement revealed that the Calcium (Ca) ion concentration were relatively higher in Ca₃SiO₅ and bredigite, and much lower in CaSiO₃ and akermanite. Accordingly, the pH values of the four silicate ceramics extracts showed a positive correlation with the particle concentrations. Meanwhile, by decreasing the particle size, higher Ca ion concentrations can be achieved, leading to the increase of aqueous pH value as well. In summary, all of the four silicate ceramics tested in our study showed antibacterial effect in a dose-dependent manner. Generally, the order of their antibacterial activity against E.coli from strong to weak is Ca₃SiO₅, bredigite, CaSiO₃ and akermanite.

Keywords

silicate ceramics / antibacterial activity / specific surface area / aqueous pH / ionic concentration

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