Synthesis and characterization of a novel pH-sensitive complex for drug release

Dongying Xu; Guangji Li; Zhengfu Liao; Xudong Chen

doi:10.1007/s11595-010-1024-9

Journal of Wuhan University of Technology Materials Science Edition ›› 2010, Vol. 25 ›› Issue (1) : 24 -27. DOI: 10.1007/s11595-010-1024-9

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Synthesis and characterization of a novel pH-sensitive complex for drug release

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Abstract

A novel pH-sensitive complex was prepared by using oxidized konjac glucomannan and 4-aminosalicylic acid (4-ASA) through glutaraldehyde as a cross-linking agent. The product was characterized by FTIR and ¹³C NMR spectra, and the thermogravimetric analysis was also studied. The drug release studies in vitro showed that the amount of 4-ASA released from the complex was about 4%, 56% and 17% after 12 h at pH 1.2, 6.8 and 7.4, respectively. The data demonstrate that the rate of the drug release of the complex can be more effectively controlled by pH value. The results showed that the novel pH-sensitive complex could be potentially useful for colon-targeting drug delivery system.

Keywords

konjac glucomannan / pH-sensitivity / drug release

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Dongying Xu, Guangji Li, Zhengfu Liao, Xudong Chen. Synthesis and characterization of a novel pH-sensitive complex for drug release. Journal of Wuhan University of Technology Materials Science Edition, 2010, 25(1): 24-27 DOI:10.1007/s11595-010-1024-9

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