Effect of ultrafine grinding on dissolving-out quantity of tanshinone IIA from Radix salvia miltiorrhiza

Yanli Su; Zhengyi Fu; Peiyan Ma; Weimin Wang; Jinyong Zhang

doi:10.1007/s11595-009-6973-5

Journal of Wuhan University of Technology Materials Science Edition ›› 2009, Vol. 24 ›› Issue (6) : 973 -976. DOI: 10.1007/s11595-009-6973-5

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Effect of ultrafine grinding on dissolving-out quantity of tanshinone IIA from Radix salvia miltiorrhiza

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Abstract

In order to improve the bioavailability, Radix salvia miltiorrhiza raw powder mixed with distilled water (5.5wt%) was ultrafinely ground to nanosize particles using HSCS pulverizer, and the dissolving-out quantity of tanshinone IIA in the filtrate that obtained from nanoparticles suspension and raw powder marinated in water for different time was determined by HPLC. The experimental results show that raw powder can be ultrafinely ground to 133.5 nm at 1500 r/min for 50 min and the molecular structure of active ingredients doesnot change, and the dissolving-out quantity of tanshinone IIA obtained from the filtrate is increased greatly from 12.77 µg/g to 54.55 µg/g.

Keywords

Radix salvia miltiorrhiza / tanshinoe IIA / HPLC / dissolving-out quantity

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Yanli Su, Zhengyi Fu, Peiyan Ma, Weimin Wang, Jinyong Zhang. Effect of ultrafine grinding on dissolving-out quantity of tanshinone IIA from Radix salvia miltiorrhiza. Journal of Wuhan University of Technology Materials Science Edition, 2009, 24(6): 973-976 DOI:10.1007/s11595-009-6973-5

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