Preparation and activity of a nanometer anti-microbial polyurethane

Abstract

A novel way for photo-immobilization with interferon- α (IFN- α) on the surface of polyurethane (PU) material, which makes PU condom more effective function in the future, was investigated. A kind of photoactive arylazide-4-azidobenzoic acid was modified to IFN- α with the confirmation of IR and Raman spectrum. Micro morphology of the photo-immobilized cell factors was observed by FESEM as well as CSLM at the level of nanometer. Finally, the product with elementary test of anti-microbial was also evaluated.

Keywords

polyurethane (PU) / interferon-α (IFN- α) / photo-immobilization / anti-microbial

References

[1] Yue H. X., Liu X. Z., Zhang Z. H., . Preclinical Trial of Feasibility and Acceptability of Polyurethane Condom[J]. Sichuan Medical Journal, 2004, 25(11): 1194-1195.

[2] Gustafsson J., Torres J., Grau C. Breakage and Acceptability of a Polyurethane Condom: A Randomized, Controlled Study[J]. Fam. Plann. Perspect, 1998, 30(2): 73-78.

[3] Tullet J. Kristiansen. Safety Functionality and Acceptability of a Prototype Polyurethane Condom[J]. Adv. Contraception, 1997, 13(4): 439-510.

[4] Searle S. R., Casellea G. The Male Polyurethane Condom: A Review of Current Knowledge[J]. Contraception, 1996, 53(3): 141

[5] Ron G. F., Terri L. W., Anita L. N., . Evaluation of the Efficacy of a Polyurethane Condom: Results from a Randomized, Controlled Clinical Trial[J]. Family Planning Perspectives, 1999, 31(2): 81-87.

[6] Terri L. W., Ron G. F., Karen P., . Evaluation of the Efficacy of a Nonlatex Condom: Results from a Randomized, Controlled Clinical Trail[J]. Perspectives on Sexual and Rreproductive Health, 2003, 35(2): 79-86.

[7] Gutterman J. U. Cytokine Therpecctics: Lesson from Interferons[J]. Proc. Natl. Acad. Sci. USA, 1994, 91: 1025-1198.

[8] Matsuda T., Sugawara T. Novel Surface Graft Copolymerization Method with Micron-order Regional Precision[J]. Macromolecules, 1994, 27: 7809-7814.

[9] Matsuda T., Sugawara T. Photochemical Protein Fixation on Polymer Surface via Derivatized Phenyl Azido Group[J]. Langmuir, 1995, 11: 2272-2276.

[10] Matsuda T., Sugawara T. Control of Cell Adhesion, Migration and Orientation on Photochemically Microprocessed Surfaces[J]. J. Biomed. Mater. Res., 1996, 32: 165-169.

[11] Ito Y., Chen G. P., Guan Y. Q., . Patterned Immobiliation of Thermo-responsive Polymer[J]. Langmuir, 1997, 13: 2756-2759.

[12] Ito Y., Hayashi M., Imanishi Y., . Gradient Micropattern Immobilizeation of Heparin and Its Interaction with Cells [J]. Biomater. Sci. Polym. Ed., 2001, 12: 367-370.

[13] Liu H., Ito Y. Gradient Micropattern Immobilizationg of a Thermoresponsive Polymer to Investigate Its Effect on Cell Behavior[J]. Biomed. Mater. Res., 2003, 67A: 1424-1428.

[14] Ito Y., Hasuda H., Yamauchi T., . Immobilization of Erythropoietin to Culture Erythropoietin-dependent Human Leukemia Cell Line[J]. Biomaterials, 2004, 25: 2293-2295.

[15] Kang I., Kim J. Co-culture of Hepatocytes and Fibroblasts by Micropatterned Immobilization of β-galactose Derivatives[J]. Biomaterials, 2004, 25: 4225-4229.

[16] Guan Y. Q. Effects of Serum Protein on Sto Cells Selective Detachment[J]. Acta Polymerica Sinica, 1999, 6: 656-659.

[17] Guan Y. Q., Guo B. J. Inhibition Activity of Spirulina Platensis Proteins Photo-immobilization Biomaterial on Proliferation of Cancer Cells[J]. Journal of Biomedical Engineering, 2002, 19(1): 1-5.

[18] Guan Y. Q., He L. M., Cai S. M., . Anti-cervix-cancer Effect of the Co-immobilized Tumor Necrosis Factor-α and Interferon-r[J]. Journal of Materials Science & Technology, 2006, 22(2): 200-208.

[19] Guan Y. Q., Zhou T. H. A Study on the Anti-cancer Properties of Long-term Administration of a Cytokine- based Carrier Drug System[J]. Tissue Engineering, 2006, 12(4): 1072-1075.

[20] Ju J. F., Li C. J. Preparation of Composed Nanometer TiO₂ Bactericide and Finishing of Textiles[J]. Textile Auxiliaries, 2005, 22(3): 37-39.

[21] Tian C. S., Jiang Y. F., Li T. J. Fluorescence Spectrum of the Interaction of Interferon with 5-Chloro-uracil[J]. Acta Scientiarum Naturalium Universitatis Jilinensis, 1998, 4: 71-74.

[22] Philip B., Laura G. Science at the Atomic Scale[J]. Nature, 1992, 355: 761-766.

[23] Lanotte L., Ausanio G. Particle Dimension Effects on Magnetization and Strain Sensitivity for a Composite of Nickel Particles in Silicone Matrix[J]. Journal of Magnetism and Magnetic Materials, 2004, 272–276: 1533-1535.

[24] Zhao Q., Pang X. F., . The Application of Nanotechnology in Life Science[J]. Physics, 2006, 4: 46-48.

[25] Xu H. Y. Progress of Nanotechnology in Biomedical Engineering Area[J]. Chinese Journal of Biomedical Engineering, 2005, 6: 6-11.

[26] Yang Z. M., Xing W. Y., Wang Y. P. Nanoparticle and Advance in Nanochemistry[J]. Yunnan Chemical Technology, 2000, 1: 22-25.