Preparation and characterization of ferromagnetic calcium alginate complex gel

Abstract

Fe₃O₄ suspension, derived from chemical co-precipitation and subsequent ultrasonic treatment, was embedded into calcium alginate to form complex gel. Both gel beads and injectable gel floc were obtained by slightly tailoring the preparation condition. SEM analysis showed that the iron oxide was dispersed homogenously in nanometer. TGA profiles revealed that the content of Fe₃O₄ in beads was about 7.2%.

Keywords

calcium alginate / Fe₃O₄ / complex / gel / preparation

References

[1] Gupta A. K., Gupta M. Synthesis and Surface Engineering of Iron Oxide Nanoparticles for Biomedical Applications[J]. Biomaterials, 2005, 26: 3 995-4 021.

[2] Gelbrich T., Feyen M., Schmidt A. M. Magnetic Thermoresponsive Core-shell Nanoparticles[J]. Macromolecules, 2006, 39: 3 469-3 472.

[3] Ramírez L. P., Landfester K. Magnetic Polystyrene Nanoparticles with a High Magnetite Content Obtained by Miniemulsion Processes[J]. Macromol. Chem. Phys., 2003, 204: 22-31.

[4] Ding Y., Hu Y., Jiang X. Q., . Polymer-monomer Pair as a Reaction System for the Synthesis of Magnetic Fe₃O₄-polymer Hybrid Hollow Nanospheres[J]. Angew. Chem. Int. Ed., 2004, 43: 6 369-6 372.

[5] Li Z., Sun Q., Gao M. Y. Preparation of Water-soluble Magnetite Nanocrystals from Hydrated Ferric Salts in 2-pyrrolidone: Mechanism Leading to Fe₃O₄[J]. Angew. Chem. Int. Ed., 2005, 44: 123-126.

[6] Deng Y. H., Yang W. L., Wang C. C., . A Novel Approach for Preparation of Thermoresponsive Polymer Magnetic Microspheres with Core-shell Structure[J]. Adv. Mater., 2003, 15: 1 729-1 732.

[7] Häfeli U. O. Magnetically Modulated Therapeutic Systems[J]. Int. J. Pharm., 2004, 277: 19-24.

[8] Li X. H., Zhang D. H., Chen J. S. Synthesis of Amphiphilic Superparamagnetic Ferrite/Block Copolymer Hollow Submicrospheres[J]. J. Am. Chem.Soc., 2006, 128: 8 382-8 383.

[9] Drury J. L., Mooney D. J. Hydrogels for Tissue Engineering: Scaffold Design Variables and Applications[J]. Biomaterials, 2003, 24: 4 337-4 351.

[10] Gu F., Amsden B., Neufeld R. Sustained Delivery of Vascular Endothelial Growth Factor with Alginate Beads[J]. J. Control. Release, 2004, 96: 463-472.

[11] Balakrishnan B., Jayakrishnan A. Self-cross-linking Biopolymers as Injectable in Situ Forming Biodegradable Scaffolds[J]. Biomaterials, 2005, 26: 3 941-3 951.

[12] Kroll E., Winnik F. M., Ziolo R. F. In situ Preparation of Nanocrystalline Fe₂O₃ in Iron (II) Cross-linked Alginate Gels[J]. Chem. Mater., 1996, 8: 1 594-1 596.

[13] Nishio Y., Yamada A., Ezaki K., . Preparation and Magnetometric Characterization of Iron-oxide-containing Alginate/PVA Networks[J]. Polymer, 2004, 45: 7 129-7 136.

[14] Ménager C., Sandre O., Mangili J., . Preparation and Swelling of Hydrophilic Magnetic Microgels[J]. Polymer, 2004, 45: 2 475-2 481.

[15] Yu J. G., Guo H., Davis S. A., . Fabrication of Hollow Inorganic Microspheres by Chemically Induced Self-transformation[J]. Adv. Funct. Mater., 2006, 16: 2035-2041.

[16] Hoffman A. S. Hydrogels for Biomedical Applications[J]. Adv. Drug Deliv. Rev., 2002, 43: 3-12.

[17] Cheng B., Lei M., Yu J. G., . Preparation of Monodispersed Cubic Calcium Carbonate Particles via Precipitation Reaction[J]. Mat. Lett., 2004, 58: 1 565-1 570.

[18] Xiao C. M., Zhou M., Lin X. D., . Chemical Modification of Calcium Alginate Gel Beads for Controlling the Release of Insect Repellent N, N-diethyl-3-methylbenzamide[J]. J. Appl. Polym. Sci., 2006, 102: 4 850-4 855.