Preparation and degradation characteristics of poly (d, l-lactide) composite films

Lei Chen; Yuhua Yan; Jianhua Li; Shipu Li

doi:10.1007/s11595-006-4691-9

Journal of Wuhan University of Technology Materials Science Edition ›› 2007, Vol. 22 ›› Issue (4) : 691 -694. DOI: 10.1007/s11595-006-4691-9

Article

Preparation and degradation characteristics of poly (d, l-lactide) composite films

Lei Chen ¹
, Yuhua Yan ¹
, Jianhua Li ¹
, Shipu Li ¹^,^{^{^d}}

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Abstract

PDLLA/CHI/β-TCP/NGF composite films were prepared by a solvent evaporation method. The degradation characteristics of the poly (d, l-lactide) composite films were studied in vitro and in vivo. The acidity produced by poly (d, l-lactide) materials was not obvious. Adding chitosan and β-TCP can relieve the acidity problem and improve strength performance of films. The NGF has influences on the degradation characteristics of films. It is verified that PDLLA/CHI/β-TCP/NGF composite films prepared by solvent evaporation method have excellent degradation characteristics. It can be used as a perfect biomaterial for repairing nerve injuries.

Keywords

poly (d, l-lactic acid) (PDLLA) / chitosan (CHI) / β-TCP / nerve growth factor (NGF) / degradation characteristics

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Lei Chen, Yuhua Yan, Jianhua Li, Shipu Li. Preparation and degradation characteristics of poly (d, l-lactide) composite films. Journal of Wuhan University of Technology Materials Science Edition, 2007, 22(4): 691-694 DOI:10.1007/s11595-006-4691-9

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