Biocompatibility of tri-block bone-matrix material in vitro

Deyu Duan; Qixin Zheng; Jie Hao; Xiaodong Guo

doi:10.1007/s11595-005-2384-7

Journal of Wuhan University of Technology Materials Science Edition ›› 2007, Vol. 22 ›› Issue (2) : 284 -287. DOI: 10.1007/s11595-005-2384-7

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Biocompatibility of tri-block bone-matrix material in vitro

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Abstract

To evaluate the biocompatibility of poly(lactic acid/glycolic acid/ asparagic acid-co-polyethylene glycol)(PLGA-[ASP-PEG]) tri-block copolymer in vitro, L929 fibroblast was co-cultured with the copolymer for cytotoxicity, hemolysis and pyrogen tests. And, compared with PLGA, the adhesiveness rate of the copolymer was calculated. The experimental results show that the toxicity gradation of the material was 0–1; L929 fibroblasts had a good cell morphology and proliferated rapidly on the surface of the material; hemolysis ratio was 3.08%; there was no pyrogen reaction. The adhesiveness of PLGA-[ASP-PEG] was better than that of the PLGA’s(P<0.05). The results confirm that the PLGA-[ASP-PEG] has a good biocompatibility.

Keywords

tissue engineering / biomaterial / polylactic acid(PLA) / biocompatibility

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Deyu Duan, Qixin Zheng, Jie Hao, Xiaodong Guo. Biocompatibility of tri-block bone-matrix material in vitro. Journal of Wuhan University of Technology Materials Science Edition, 2007, 22(2): 284-287 DOI:10.1007/s11595-005-2384-7

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