Intercalation of amido cationic drug with montmorillonite

Junping Zheng; Hongyan Wang; Hong Zhuang; Lifei Xi; Kangde Yao

doi:10.1007/s11595-005-2250-4

Journal of Wuhan University of Technology Materials Science Edition ›› 2007, Vol. 22 ›› Issue (2) : 250 -252. DOI: 10.1007/s11595-005-2250-4

Article

Intercalation of amido cationic drug with montmorillonite

Author information +

History +

PDF

Abstract

The intercalation of drug molecules with montmorillonit (MMT) using Acyclovir (ACV) as the model drug was focused on. The optimum conditions were studied based on orthogonal design, such as intercalation time and temperature. The intercalation composites were characterized by X-ray diffraction (XRD), Fourier transformed infrared (FT-IR), and thermogravimetric analysis (TGA). The experimental results reveal that ACV is successfully intercalated into the interlayers of MMT. The in vitro release experiments reveal that ACV is released from MMT steadily and pH dependent

Keywords

montmorillonite / acyclovir / intercalation / in vitro release

Cite this article

Download citation ▾

Junping Zheng, Hongyan Wang, Hong Zhuang, Lifei Xi, Kangde Yao. Intercalation of amido cationic drug with montmorillonite. Journal of Wuhan University of Technology Materials Science Edition, 2007, 22(2): 250-252 DOI:10.1007/s11595-005-2250-4

登录浏览全文

4963

注册一个新账户忘记密码

References

Publishing order | Descend order by publishing year | Descend order by cited within

[1]	Lin F. H., Lee Y. H., Jian C. H., . A Study of Purified Montmorillonite Intercalated with 5-Fluorouracil as Drug Carrier[J]. Biomaterials, 2002, 23(9): 1981-1987.

[2]	Vergin H., Kikuta C., Mascher H., . Pharmacokinetics and Bioavailability of Different Formulations of Acyclovir[J]. Drug Res., 1995, 45(1): 508-519.

[3]	Meadows K. C., Dressman J. B. Mechanism of Acyclovir Uptake in Rat Jejunum[J]. Pharm. Res., 1990, 7(3): 299-303.

[4]	Lewis L. D., Fovle A. S. E., Bittiner S. B., . Human Gastrintestinal Absorption of Acyclovir from Tablets Duodenal Infusion and Sipped Solution[J]. Br. J. Clin. Pharmacol., 1986, 21(3): 459-463.

[5]	De Brabander C., Vervaet C., Remon J. P. Development and Evaluation of Sustained Release Mini-matrices Prepared via Hot Melt Extrusion[J]. J. of Controlled Release, 2003, 89(2): 235-247.

[6]	Zheng J. P., Li P., Yao K. D. Gelatin/Montmorillonite Hybrid Nanocomposite.I. Preparation and Properties[J]. J. Appl. Polym. Sci., 2002, 86(5): 1189-1194.

[7]	Komadel P., Bujdak J., Madejova J., . Effect of Non-swelling Layers on the Dissolution of Reduced-charge Montmorillonite in Hydrochloric Acid[J]. Clay Miner., 1996, 31(3): 333-345.

[8]	Nasser A., Gal M., Yariv S., . Adsorption of Alachlor by Montmorillonite[J]. J Thermal Anal, 1997, 50(1): 257-268.

[9]	Zhou J., Lu R. Z. Degradation Mechanism of a New Antiviral Agent, Valaclclovir, in Aqueous Solution[J]. J. of Sichuan Continuing Education College of Ms, 1998, 17(3): 129-131.

[10]	Hutchison C. S. Laboratory Handbook of Petrographic Techniques[M], 1973. New York: McGraw-Hill Book Co.. 456

[11]	W S Shalaby, W E Blevind, K Park. Gastric Retention Enzyme-digestible Hydrogels in the Canine Stomach under Fasted and Fed Conditions[J]. ACS Symposium Series, 1991, No.469:237–248