Study on Z-H/BMP toughened compound artificial bone and its osteogenesis

Abstract

The purpose of this study was to find a kind of new artificial bone for anterior spinal fusion. ZrO₂ stabilized by Y₂O₃(Y-PSZ), porous hydroxyapatite (HA) and bone morphogenetic protein (BMP) were used to make artificial compound bone (Y₂O₃) ZrO₂-HA/BMP(Z-H/BMP), whose function was tested, microstructure and mineralogic composition constitution were analysised by SEM and XRD, and the corresponding animal tests were porformed. Osteogenesis of the material was observed by eyes, histology and SEM. Experimental results show that the component and ossific activity of Z-H/BMP were satisfactory.

Keywords

bioceramics / bone morphogenetic protein / spinal fusion / bone implantation

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