IL-1B, IL-6 and TNF-a change of experimental knee joint degeneration model and effect of local loosening therapy
Ying Zhang , Jiang-nan Zhou , Jia-bang Li , Jing-cai Zhou , Zhong-huan Zhou
Journal of Central South University ›› 2005, Vol. 12 ›› Issue (Suppl 1) : 356 -358.
IL-1B, IL-6 and TNF-a change of experimental knee joint degeneration model and effect of local loosening therapy
Objective To observe IL-1B, IL-6 and TNF-a level change of the joint fluid in the experimental knee joint degeneration and the effect of the local loosening therapy. Methods Thirty rabbits were divided into 3 groups at random: ten in the normal contrast group, ten in the blank model group and ten in the loosening therapy group to observe the IL-1B, IL-6 and TNF-a change of the joint fluid before and after the treatment in each group. Result IL-1B, IL-6 and TNF-a level in the blank model group was obviously higher than that in the normal group. (P<0.05). IL-1B, IL-6 and TNF-a level in the treatment group was obviously lower than that in the normal group. (P<0.05). Conclusions 1) IL-1B, IL-6 and TNF-a level of the joint fluid in the blank model group was obviously higher than that in the normal group. 2) Loosening soft tissues of the knees can improve IL-1B, IL-6 and TNF-a level of the joint fluid.
experimental knee joint degeneration / local loosening therapy
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