Feasibility study of marrow stromal cells transplantation into guinea pig cochlea

Abstract

Objective This pilot-study was designed to evaluate the feasibility of cell transplantation into guinea pig cochlea. Methods Marrow stromal cells were labeled with DAPI, and then implanted into the cochlea of guinea pig. The existence and differentiation trend were observed roughly two weeks later by histologic analysis. Results Transplant-derived marrow stem cells survived in cochlea two weeks later with a trend of attaching to cochlear architecture but not differentiate into neuron. Conclusions Transplant-derived marrow stem cells can survive in cochlea, and cell transplantation may be a useful strategy in inner ear diseases.

Keywords

cell transplantation / marrow stem cell / neurotrophin / neurofilament protein