Injectable antibacterial polyurethane hydrogel for infected wound therapy

Abstract

The fabrication of injectable hydrogels with multiple functions and effective promotion of wound repair has a great prospect in treatment of bacterial infected wounds. Herein, we fabricated polyurethane hydrogel via a catalyst-free click reaction, in which aminoporphyrin (TPP-NH₂) being covalently incorporated into a polyurethane network crosslinked with L-cystine (L-Cys) to form an injectable, self-healing levofloxacin-loaded porphyrin polyurethane hydrogel (APU-TPP-Lev gel). In weakly acidic environments, the gel released antibiotics and generated reactive oxygen species (ROS) under red light irradiation, synergistically eliminating Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) to demonstrate highly effective contact antimicrobial activity. Furthermore, the hydrogel exhibits excellent biocompatibility, significantly promoting the healing of infected wounds after injection and light exposure, indicating broad application prospects in the treatment of bacterial infected wounds.

Keywords

polyurethane / hydrogel / antibacterial / photosensitizer

Acknowledgements

This research was financially supported by the National Natural Science Foundation of China (52222307), and Jilin Province Development and Reform Commission (2023C028-4).

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