Experimental genomics: The application of DNA microarrays in cellular and molecular biology studies

Abstract

The genome sequence information in combination with DNA microarrays promises to revolutionze the way of cellular and molecular biological research by allowing complex mixtures of RNA and DNA to interrogated in a parallel and quantitative fashion. DNA microarrays can be used to measure levels of gene expression for tens of thousands of gene simultaneously and take advantage of all available sequence information for experimental design and data interpretation in pursuit of biological understanding. Recent progress in experimental genomics allows DNA microarrays not simply to provide a catalogue of all the genes and information about their function, but to understand how the components work together to comprise functioning cells and organisms. This brief review gives a survey of DNA microarrays technology and its applications in genome and gene function analysis, gene expression studies, biological signal and defense system, cell cycle regulation, mechanism of transcriptional regulation, proteomics, and the functionality of food component.

Keywords

Experimental genomics / Sequence information / DNA microarrays / Gene expression / Functional analysis / Q789 / A