Ethylbenzene exposure in North America - an update

Janet E. Kester , David A. Morgott

Journal of Environmental Exposure Assessment ›› 2023, Vol. 2 ›› Issue (1) : 1

PDF
Journal of Environmental Exposure Assessment ›› 2023, Vol. 2 ›› Issue (1) :1 DOI: 10.20517/jeea.2022.22
Review

Ethylbenzene exposure in North America - an update

Author information +
History +
PDF

Abstract

Chronic ethylbenzene exposures and attendant potential health risks for United States children and prospective parents were first evaluated under the United States Environmental Protection Agency’s Voluntary Children’s Chemical Evaluation Program. Using updated data and methods, a 2015 reevaluation observed declines in ethylbenzene releases and concentrations in ambient and indoor air. Both assessments identified inhalation as the dominant exposure route and smoking as the greatest contributor, with dietary intake much lower. Children’s exposure concentrations were similar to that of adults, but their intakes were higher. Neither breastfeeding nor toy mouthing was a significant source. This report updates the previous assessments, summarizing current ethylbenzene concentrations in air and foods, exposures during the use of household and consumer products, nationally representative biomonitoring data, including expanded demographic groups, and a new survey of worker exposures in styrene production facilities. General population ethylbenzene exposures appear to have declined for all age groups. The ethylbenzene/styrene chain of commerce contributes an estimated 0.1% to total air emissions and 7%-12% to dietary concentrations. Total estimated ethylbenzene intakes are consistent with biomonitoring data. Lactational transfer is not a significant exposure pathway for breastfed infants. Production workers’ exposure is well below occupational guidelines. Updated exposure estimates for each pathway suitable for potential health risk assessment are proposed.

Keywords

Ethylbenzene / exposure assessment / VCCEP / children / personal air / dietary exposure / hobby exposure / occupational exposure / biomonitoring

Cite this article

Download citation ▾
Janet E. Kester, David A. Morgott. Ethylbenzene exposure in North America - an update. Journal of Environmental Exposure Assessment, 2023, 2(1): 1 DOI:10.20517/jeea.2022.22

登录浏览全文

4963

注册一个新账户 忘记密码

References

[1]

U.S. Environmental Protection Agency (USEPA). Voluntary Children’s Chemical Evaluation Program; notice. 2000. Available from: https://www.govinfo.gov/content/pkg/FR-2000-12-26/pdf/00-32767.pdf. [Last accessed on 9 Nov 2022]

[2]

Williams PR,Briggs DW.VCCEP pilot: progress on evaluating children’s risks and data needs.Risk Anal2006;26:781-801

[3]

Ashley DL,Cardinali FL,Wooten JV.Blood concentrations of volatile organic compounds in a nonoccupationally exposed US population and in groups with suspected exposure.Clin Chem1994;40:1401-4

[4]

Wallace LA,Hartwell TD.The TEAM study: personal exposures to toxic substances in air, drinking water, and breath of 400 residents of New Jersey, North Carolina, and North Dakota.Environ Res1987;43:290-307

[5]

Toxicology Excellence for Risk Assessment (TERA). Voluntary Children’s Chemical Evaluation Program (VCCEP) peer consultation meeting on ethylbenzene. Available from: https://tera.org/Peer/VCCEP/Ethylbenzene/EBWelcome.html. [Last accessed on 9 Nov 2022]

[6]

American Chemistry Council Ethylbenzene Panel (ACC). Voluntary Children’s Chemical Evaluation Program (VCCEP) Tier 1 pilot submission for ethylbenzene (CAS No. 100-41-4) 2007. Available from: https://tera.org/Peer/VCCEP/Ethylbenzene/VCCEP%20Ethylbenzene%20Revised%20Doc%20-august%2010%202007.pdf [Last accessed on 9 Nov 2022]

[7]

U.S. Environmental Protection Agency Office of the Inspector General (USEPA OIG). EPA’s Voluntary Chemical Evaluation Program Did Not Achieve Children’s Health Protection Goals. Report No. 11-P-0379. 2011. Available from: https://www.epa.gov/sites/default/files/2015-10/documents/20110721-11-p-0379.pdf [Last accessed on 9 Nov 2022]

[8]

Agency for Toxic Substances and Disease Registry (ATSDR). Toxicological profile for ethylbenzene. Available from: https://www.atsdr.cdc.gov/ToxProfiles/tp110.pdf [Last accessed on 9 Nov 2022]

[9]

IHS Markit. Ethylbenzene. Chemical economics handbook. Available from: https://ihsmarkit.com/products/ethylbenzene-chemical-economics-handbook.html. [Last accessed on 9 Nov 2022]

[10]

Miller R,Poole A.Styrene production, use, and human exposure.Crit Rev Toxicol1994;24:S1-S10

[11]

International Agency for Research on Cancer (IARC). IARC monographs on the evaluation of carcinogenic risks to humans. Volume 82: some traditional herbal medicines, some mycotoxins, naphthalene, and styrene. Available from: https://monographs.iarc.who.int/wp-content/uploads/2018/06/mono82.pdf [Last accessed on 9 Nov 2022]

[12]

Agency for Toxic Substances and Disease Registry (ATSDR), Department of Health and Human Services PHS. Toxicological Profile for Styrene. Available from: https://www.atsdr.cdc.gov/toxprofiles/tp53.pdf [Last accessed on 9 Nov 2022]

[13]

Environment and Climate Change Canada/Health Canada. Screening Assessment Report Ethylbenzene Chemical Abstracts Service Registry Number 100-41-4. 2016. Available from: https://www.ec.gc.ca/ese-ees/FE722725-DA50-458C-91C8-558DFEC57996/FSAR_Ethylbenzene_EN.pdf [Last accessed on 9 Nov 2022]

[14]

World Health Organization (WHO). Ethylbenzene; 1996. Available from: https://apps.who.int/iris/handle/10665/41867?locale-attribute=pt [Last accessed on 9 Nov 2022]

[15]

International Agency for Research on Cancer (IARC), World Health Organization. IARC monographs on the evaluation of carcinogenic risks to humans. Volume 77: some industrial chemicals. Available from: https://monographs.iarc.who.int/wp-content/uploads/2018/06/mono77.pdf [Last accessed on 9 Nov 2022]

[16]

U.S. Environmental Protection Agency (USEPA). Air Data: Annual Summary Data. Last Modified 11/24/2021. Accessed December 2021. Available from: https://aqs.epa.gov/aqsweb/airdata/download_files.html#Annual. [Last accessed on 9 Nov 2022]

[17]

U.S. Environmental Protection Agency (USEPA). Risk Assessment Guidance for Superfund Volume I: Human Health Evaluation Manual (Part F). Available from: https://www.epa.gov/sites/default/files/2015-09/documents/rags_a.pdf [Last accessed on 9 Nov 2022]

[18]

Sweeney LM,Kirman CR.Risk assessments for chronic exposure of children and prospective parents to ethylbenzene (CAS No. 100-41-4).Crit Rev Toxicol2015;45:662-726

[19]

Aurisano N,Milà I Canals L,Fantke P.Chemicals of concern in plastic toys.Environ Int2021;146:106194

[20]

Willem H.Chemical emissions of residential materials and products: review of available information. 2010.

[21]

Kim YM,Harrison RM.Concentrations and sources of VOCs in urban domestic and public microenvironments.Environ Sci Technol2001;35:997-1004

[22]

Derbez M,Le Ponner E,Ribéron J.Indoor air quality in energy-efficient dwellings: levels and sources of pollutants.Indoor Air2018;28:318-38

[23]

Saarela K,Laine-ylijoki J,Nieuwenhuijsen M.Exposure of population and microenvironmental distributions of volatile organic compound concentrations in the EXPOLIS study.Atmospheric Environ2003;37:5563-75

[24]

Harrison R,Baker S,Meddings C.Measurement and modeling of exposure to selected air toxics for health effects studies and verification by biomarkers.Res Rep Health Eff Inst2009;3-96:9-100

[25]

Delgado-Saborit JM,Meddings C,Harrison RM.Relationship of personal exposure to volatile organic compounds to home, work and fixed site outdoor concentrations.Sci Total Environ2011;409:478-88

[26]

Borghi F,Mandaglio S.Estimation of the inhaled dose of pollutants in different micro-environments: a systematic review of the literature.Toxics2021;9:140 PMCID:PMC8231583

[27]

Vardoulakis S,Steinle S.Indoor exposure to selected air pollutants in the home environment: a systematic review.Int J Environ Res Public Health2020;17:8972 PMCID:PMC7729884

[28]

Klepeis NE,Ott WR.The national human activity pattern survey (NHAPS): a resource for assessing exposure to environmental pollutants.J Expo Anal Environ Epidemiol2001;11:231-52

[29]

Schweizer C,Bayer-Oglesby L.Indoor time-microenvironment-activity patterns in seven regions of Europe.J Expo Sci Environ Epidemiol2007;17:170-81

[30]

Edwards R,Llacqua V.Time-activity relationships to VOC personal exposure factors.Atmospheric Environment2006;40:5685-700

[31]

Jia C,Chauhan B,Kedia RJ.Exposure to volatile organic compounds (VOCs) at gas stations: a probabilistic analysis.Air Qual Atmos Health2022;15:465-77

[32]

Dodson RE,Spengler JD,Bennett DH.Influence of basements, garages, and common hallways on indoor residential volatile organic compound concentrations.Atmospheric Environment2008;42:1569-81

[33]

Wallace LA,Leaderer B,Sheldon L.Emissions of volatile organic compounds from building materials and consumer products.Atmospheric Environment (1967)1987;21:385-93

[34]

Wallace LA.Personal air exposures and breath concentrations of benzene and other volatile hydrocarbons for smokers and nonsmokers.Toxicol Lett1986;35:113-6

[35]

Wallace LA,Hartwell TD,Michael LC.The influence of personal activities on exposure to volatile organic compounds.Environ Res1989;50:37-55

[36]

Wallace L,Hartwell TD,Ziegenfus R.Exposures to benzene and other volatile compounds from active and passive smoking.Arch Environ Health1987;42:272-9

[37]

Wallace LA,Hartwell TD,Sheldon LS.Personal exposures, indoor-outdoor relationships, and breath levels of toxic air pollutants measured for 355 persons in New Jersey.Atmos Environ1985;19:1651-61

[38]

Wallace LA,Hartwell TD,Sparacino C.Total exposure assessment methodology (team) study: personal exposures, indoor-outdoor relationships, and breath levels of volatile organic compounds in New Jersey.Environ Int1986;12:369-87

[39]

Wallace LA,Hartwell TD,Zelon H.The California TEAM study: breath concentrations and personal exposures to 26 volatile compounds in air and drinking water of 188 residents of Los Angeles, Antioch, and Pittsburg, CA.Atmos Environ1988;22:2141-63

[40]

Wallace LA.Comparison of risks from outdoor and indoor exposure to toxic chemicals.Environ Health Perspect1991;95:7-13 PMCID:PMC1568414

[41]

Wallace LA.Personal exposure to 25 volatile organic compounds. EPA’s 1987 team study in Los Angeles, California.Toxicol Ind Health1991;7:203-8

[42]

Jia C,Batterman S.Distributions of personal VOC exposures: a population-based analysis.Environ Int2008;34:922-31

[43]

Lin YS,Rappaport SM.Relationships between levels of volatile organic compounds in air and blood from the general population.J Expo Sci Environ Epidemiol2008;18:421-9

[44]

Adgate JL,Stroebel C,Sexton K.Personal, indoor, and outdoor VOC exposures in a probability sample of children.J Expo Anal Environ Epidemiol2004;14 Suppl 1:S4-S13

[45]

Edwards RD,Saarela K.VOC concentrations measured in personal samples and residential indoor, outdoor and workplace microenvironments in EXPOLIS-Helsinki, Finland.Atmospheric Environt2001;35:4531-43

[46]

Weisel CP,Turpin BJ,Colome S.Relationships of indoor, outdoor, and personal air (RIOPA). Part I. Collection methods and descriptive analyses. Res Rep Health Eff Inst 2005;1-107: discussion109-27.

[47]

Bari MA,Wheeler AJ,Wallace LA.Source apportionment of indoor and outdoor volatile organic compounds at homes in Edmonton, Canada.Build Environ2015;90:114-24

[48]

Li Y,Zhu J.Profiles and monthly variations of selected volatile organic compounds in indoor air in Canadian homes: results of Canadian national indoor air survey 2012-2013.Environ Int2019;126:134-44

[49]

Wheeler AJ,Khouri C.Predictors of indoor BTEX concentrations in Canadian residences.Health Rep2013;24:11-7

[50]

Zhu J,Cakmak S.Nationally representative levels of selected volatile organic compounds in Canadian residential indoor air: population-based survey.Environ Sci Technol2013;47:13276-83

[51]

Xu J,Jovic B,Austin CC.Estimation of indoor and outdoor ratios of selected volatile organic compounds in Canada.Atmospheric Environ2016;141:523-31

[52]

Xie J,Sheng G,Fu J.Determination of tobacco smoking influence on volatile organic compounds constituent by indoor tobacco smoking simulation experiment. Atmos Environ 2003;37:3365-74.

[53]

Heavner DL,Ogden MW.Determination of volatile organic compounds and ETS apportionment in 49 homes.Environ Int1995;21:3-21

[54]

Heavner DL,Ogden MW.Determination of volatile organic compounds and respirable suspended particulate matter in New Jersey and Pennsylvania homes and workplaces.Environ Int1996;22:159-83

[55]

Hodgson AT,Mahanama KRR,Alevantis LE.Use of volatile tracers to determine the contribution of environmental tobacco smoke to concentrations of volatile organic compounds in smoking environments.Environ Int1996;22:295-307

[56]

Chin JY,Parker E.Levels and sources of volatile organic compounds in homes of children with asthma.Indoor Air2014;24:403-15 PMCID:PMC4057989

[57]

Dawson HE.A compilation of statistics for VOCs from post-1990 indoor air concentration studies in North American residences unaffected by subsurface vapor intrusion.Ground Water Monit Remediat2009;29:60-9

[58]

U.S. Environmental Protection Agency (USEPA). Background indoor air concentrations of volatile organic compounds in North American residences (1990-2005): a compilation of statistics for assessing vapor intrusion. Available from: https://www.epa.gov/sites/default/files/2015-09/documents/oswer-vapor-intrusion-background-report-062411.pdf [Last accessed on 9 Nov 2022]

[59]

U.S. Environmental Protection Agency (USEPA). Regional screening levels for chemical contaminants at superfund sites (november 2021). last modified november 17, 2021. Available from: https://www.epa.gov/risk/regional-screening-levels-rsls-generic-tables. [Last accessed on 9 Nov 2022]

[60]

Steinle S,Sabel CE.Quantifying human exposure to air pollution-moving from static monitoring to spatio-temporally resolved personal exposure assessment.Sci Total Environ2013;443:184-93

[61]

Symanski E,Tee PG.Demographic, residential, and behavioral determinants of elevated exposures to benzene, toluene, ethylbenzene, and xylenes among the U.S. population: results from 1999-2000 NHANES.J Toxicol Environ Health A2009;72:915-24

[62]

Buckley T,Kim S. VOC exposure in an industry-impacted community. 2005. (Report No. NUATRC Research Report Number 4). Available from: https://cfpub.epa.gov/ncer_abstracts/index.cfm/fuseaction/display.files/fileID/13927. [Last accessed on 9 Nov 2022]

[63]

Avens HJ,Insley AL,Reid RCD.Characterization of airborne BTEX exposures during use of lawnmowers and trimmers.Arch Environ Occup Health2019;74:197-205

[64]

Fontes T,Prata JC,Silva C.Exposure to BTEX in buses: the influence of vehicle fuel type.Environ Pollut2019;255:113100

[65]

Allahabady A,Ali Mohammadpour Tahamtan R.Measurement of BTEX (benzene, toluene, ethylbenzene and xylene) concentration at gas stations.Environ Health Eng Manag2022;9:23-31

[66]

Cohen Hubal EA,Aylward L.Advancing exposure characterization for chemical evaluation and risk assessment.J Toxicol Environ Health B Crit Rev2010;13:299-313

[67]

Egeghy PP,Isaacs KK.Computational exposure science: an emerging discipline to support 21st-century risk assessment.Environ Health Perspect2016;124:697-702 PMCID:PMC4892918

[68]

Ring CL,Bennett DH.Consensus modeling of median chemical intake for the U.S. population based on predictions of exposure pathways.Environ Sci Technol2019;53:719-32 PMCID:PMC6690061

[69]

Wambaugh JF,Reif DM.High-throughput models for exposure-based chemical prioritization in the ExpoCast project.Environ Sci Technol2013;47:8479-88

[70]

Wambaugh JF,Dionisio KL.High throughput heuristics for prioritizing human exposure to environmental chemicals.Environ Sci Technol2014;48:12760-7

[71]

Jolliet O,Hou P.High throughput risk and impact screening of chemicals in consumer products.Risk Anal2021;41:627-44 PMCID:PMC8246852

[72]

U.S. Environmental Protection Agency (USEPA). Exposure Factors Handbook: 2011 Edition. Washington, D.C.; 2011. Available from: https://cfpub.epa.gov/ncea/risk/recordisplay.cfm?deid=236252 [Last accessed on 9 Nov 2022]

[73]

Licina D,Bekö G,Nazaroff WW.Clothing-mediated exposures to chemicals and particles.Environ Sci Technol2019;53:5559-75

[74]

Tang W,Eisenbrand G.Estimation of human exposure to styrene and ethylbenzene.Toxicology2000;144:39-50

[75]

Sanagi MM,Nasir Z,Abu Naim A.Determination of residual volatile organic compounds migrated from polystyrene food packaging into food simulant by headspace solid phase microextraction-gas chromatography.Malaysian J Anal Scis2008;12:542-51

[76]

Bhunia K,Tang J.Migration of chemical compounds from packaging polymers during microwave, conventional heat treatment, and storage.Compr Rev Food Sci Food Saf2013;12:523-45

[77]

Melski K,Kubera H. Model study on intensified migration of volatile substances from food contacting plastic materials during repeated microwaving. Available from: http://www.ejpau.media.pl/volume6/issue1/food/art-09.html [Last accessed on 9 Nov 2022]

[78]

Marć M.An investigation of selected monoaromatic hydrocarbons released from the surface of polystyrene lids used in coffee-to-go cups.Microchem. J2017;133:496-505

[79]

Pajaro-Castro N,Olivero-Verbel J.Identification of volatile organic compounds (VOCs) in plastic products using gas chromatography and mass spectrometry (GC/MS).Rev Ambient Agua2014;9:610-20

[80]

Lin QB,Fang H,Wang ZW.Migration of styrene and ethylbenzene from virgin and recycled expanded polystyrene containers and discrimination of these two kinds of polystyrene by principal component analysis.Food Addit Contam Part A Chem Anal Control Expo Risk Assess2017;34:126-32

[81]

Ehret-Henry J,Luciani A.Styrene and ethylbenzene migration from polystyrene into dairy products by dynamic purge-and trap gas chromatography.J Food Sci1994;59:990-1001

[82]

Gramshaw JW.Compositional analysis of samples of thermoset polyester and migration of ethylbenzene and styrene from thermoset polyester into pork during cooking.Food Addit Contam1995;12:223-34

[83]

Nerín C.Behavior of some solid food simulants in contact with several plastics used in microwave ovens.J Agric Food Chem2002;50:7488-92

[84]

Nerín C,Rubio C.Potential migration release of volatile compounds from plastic containers destined for food use in microwave ovens.Food Addit Contam2002;19:594-601

[85]

Wittrig B. Monitoring volatiles in food contact packaging. Excerpted from Food Quality. Available from: https://pdf2.chromtech.net.au/pres-2001-food-pk.pdf. [Last accessed on 9 Nov 2022]

[86]

Fleming-Jones ME.Volatile organic compounds in foods: a five year study.J Agric Food Chem2003;51:8120-7

[87]

Bradley E,Layfield E,Speck D.Investigation of Chemical Migration into Take-Away and Snack Foods. 2004. (Report No. A03033).

[88]

Chiesa LM,Panseri S.Release of ethylbenzene and styrene from plastic cheese containers.Vet Res Commun2008;32 Suppl 1:S319-21

[89]

López P,Salafranca J.Efficiency of whole and skimmed powdered milk for trapping volatile compounds released from plastic containers in high-temperature applications.J Food Prot2008;71:1889-97

[90]

Hwang JB,Yeum J.HS-GC/MS method development and exposure assessment of volatile organic compounds from food packaging into food simulants.Food Addit Contam Part A Chem Anal Control Expo Risk Assess2019;36:1574-83

[91]

Arvanitoyannis IS.Migration of substances from food packaging materials to foods.Crit Rev Food Sci Nutr2004;44:63-76

[92]

Begley T,Feigenbaum A.Evaluation of migration models that might be used in support of regulations for food-contact plastics.Food Addit Contam2005;22:73-90

[93]

Lau O.Contamination in food from packaging material.J Chromatography A2000;882:255-70

[94]

Mercea P. Migration of Substances from Plastic Food Contact Materials into Foods and Food Simulants. In. SpecialChem. Available from: https://www.productip.com/kb/productipedia/compliance-resources/plastic-food-contact-materials [Last accessed on 9 Nov 2022]

[95]

Song X,Nerin C,Zhong H.Volatile non-intentionally added substances (NIAS) identified in recycled expanded polystyrene containers and their migration into food simulants.Food Packag Shelf Life2019;20:100318

[96]

Muncke J,Backhaus T.Impacts of food contact chemicals on human health: a consensus statement.Environ Health2020;19:25 PMCID:PMC7053054

[97]

Ernstoff AS,Huang L.High-throughput migration modelling for estimating exposure to chemicals in food packaging in screening and prioritization tools.Food Chem Toxicol2017;109:428-38

[98]

Hahladakis JN,Weber R,Purnell P.An overview of chemical additives present in plastics: Migration, release, fate and environmental impact during their use, disposal and recycling.J Hazard Mater2018;344:179-99

[99]

European Commission (EC). Opinion on certain aromatic hydrocarbons present in food (expressed on 20/1/1999). Available from: https://food.ec.europa.eu/system/files/2020-12/sci-com_scf_out24_en.pdf [Last accessed on 9 Nov 2022]

[100]

Polystyrene Work Group (PWG). Potential Exposure to Ethylbenzene from Food-Contact Use of Polystyrene Resins. 1997. Available from: https://documen.site/download/document-1463136_pdf [Last accessed on 9 Nov 2022]

[101]

Lickly TD,Rainey ML.A model for estimating the daily dietary intake of a substance from food-contact articles: styrene from polystyrene food-contact polymers.Regul Toxicol Pharmacol1995;21:406-17

[102]

U.S. Food & Drug Administration (FDA). Cumulative Estimated Daily Intakes (CEDI) database. Last Modified December 14, 2017. Available from: https://www.fda.gov/food/packaging-food-contact-substances-fcs/cedi-database. [Last accessed on 9 Nov 2022]

[103]

U.S. Food and Drug Administration (FDA). Total Diet Study. Last Modified 2/23/2018. Accessed August 2019. Available from: https://www.fda.gov/food/science-research-food/total-diet-study. [Last accessed on 9 Nov 2022]

[104]

Vinci RM,De Meulenaer B,Matsiko E.Occurrence of volatile organic compounds in foods from the Belgian market and dietary exposure assessment.Food Control2015;52:1-8

[105]

Cao XL,Dabeka R.Occurrence of 13 volatile organic compounds in foods from the Canadian total diet study.Food Addit Contam Part A Chem Anal Control Expo Risk Assess2016;33:373-82

[106]

U.S. Environmental Protection Agency (USEPA). Statistical Software ProUCL 5.1.00 for Environmental Applications for Data Sets with and without Nondetect Observations. 2016. Available from: https://www.epa.gov/land-research/proucl-software. [Last accessed on 9 Nov 2022]

[107]

Aylward LL,Blount BC.Chemical-specific screening criteria for interpretation of biomonitoring data for volatile organic compounds (VOCs)-application of steady-state PBPK model solutions.Regul Toxicol Pharmacol2010;58:33-44

[108]

Aylward LL,Schoeny R,Hays SM.Evaluation of biomonitoring data from the CDC National Exposure Report in a risk assessment context: perspectives across chemicals.Environ Health Perspect2013;121:287-94 PMCID:PMC3621178

[109]

Kirman CR,Blount BC,Hays SM.Evaluation of NHANES biomonitoring data for volatile organic chemicals in blood: application of chemical-specific screening criteria.J Expo Sci Environ Epidemiol2012;22:24-34

[110]

Su FC,Batterman S.Trends of VOC exposures among a nationally representative sample: analysis of the NHANES 1988 through 2004 data sets.Atmos Environ (1994)2011;45:4858-67 PMCID:PMC4335682

[111]

Centers for Disease Control and Prevention (CDC). Fourth National Report on Human Exposure to Environmental Chemicals Updated Tables, March 2021, Volume Two: NHANES 2011-2016. 2021. Available from: https://www.cdc.gov/exposurereport/ [Last accessed on 9 Nov 2022]

[112]

Centers for Disease Control and Prevention (CDC). National Report on Human Exposure to Environmental Chemicals. Available from: https://www.cdc.gov/exposurereport/index.html. [Last accessed on 9 Nov 2022]

[113]

Jain RB.Detection rates, trends in and factors affecting observed levels of selected volatile organic compounds in blood among US adolescents and adults.Environ Toxicol Pharmacol2017;56:21-8

[114]

Pollock T,Walker M,St-Amand A.Trends in environmental chemical concentrations in the Canadian population: Biomonitoring data from the Canadian Health Measures Survey 2007-2017.Environ Int2021;155:106678

[115]

Belova A,Riederer AM,Corrales MA.A method to screen US environmental biomonitoring data for race/ethnicity and income-related disparity.Environ Health2013;12:1-17

[116]

Nguyen VK,Heidt J.A comprehensive analysis of racial disparities in chemical biomarker concentrations in United States women, 1999-2014.Environ Int2020;137:105496 PMCID:PMC7137529

[117]

Churchill JE,Kaye WE.Recent chemical exposures and blood volatile organic compounds in a large population-based sample.Arch Environ Health2001;56:157-66

[118]

Chambers DM,McGuirk MF.Impact of cigarette smoking on volatile organic compound (VOC) blood levels in the U.S. population: NHANES 2003-2004.Environ Int2011;37:1321-8

[119]

Jain RB.Selected volatile organic compounds as biomarkers for exposure to tobacco smoke.Biomarkers2016;21:342-6

[120]

Doherty BT,Curry MD,Chambers D.Associations between blood BTEXS concentrations and hematologic parameters among adult residents of the US Gulf States.Environ Res2017;156:579-87

[121]

Centers for Disease Control and Prevention (CDC). Fourth National Report on Human Exposure to Environmental Chemicals Updated Tables, March 2021, Volume Four: Analysis of Chemicals Found in Cigarette Smoke in a Special Sample of U.S. Adults, NHANES 2011-2016. 2021. Available from: https://www.cdc.gov/exposurereport/ [Last accessed on 9 Nov 2022]

[122]

Faure S,Werry K,Aylward LL.Evaluation of human biomonitoring data in a health risk based context: an updated analysis of population level data from the Canadian Health Measures Survey.Int J Hyg Environ Health2020;223:267-80

[123]

Ashley DL,Hamar B.Removing the smoking confounder from blood volatile organic compounds measurements.Environ Res1995;71:39-45

[124]

Jia C,Masiak W.Blood/air distribution of volatile organic compounds (VOCs) in a nationally representative sample.Sci Total Environ2012;419:225-32

[125]

Khoury C,Haines D,Malowany M.Human biomonitoring reference values for some non-persistent chemicals in blood and urine derived from the Canadian health measures survey 2009-2013.Int J Hyg Environ Health2018;221:684-96

[126]

Kawai T,Ikeda M.Biological monitoring of occupational ethylbenzene exposure by means of urinalysis for un-metabolized ethylbenzene.Ind Health2019;57:525-9 PMCID:PMC6685802

[127]

Janasik B,Wesołowski W.Unmetabolized VOCs in urine as biomarkers of low level occupational exposure.Int J Occup Med Environ Health2010;23:21-6

[128]

Kawai T,Mizunuma K.Comparative evaluation of urinalysis and blood analysis as means of detecting exposure to organic solvents at low concentrations.Int Arch Occup Environ Health1992;64:223-34

[129]

Janasik B,Jałowiecki P.Excretion of unchanged volatile organic compounds (toluene, ethylbenzene, xylene and mesitylene) in urine as result of experimental human volunteer exposure.Int Arch Occup Environ Health2008;81:443-9

[130]

Knecht U,Woitowitz HJ.Biological monitoring of standardized exposure to ethylbenzene: evaluation of a biological tolerance (BAT) value.Arch Toxicol2000;73:632-40

[131]

Jang JY,Kim S.Biological monitoring of workers exposed to ethylbenzene and co-exposed to xylene.Int Arch Occup Environ Health2001;74:31-7

[132]

Bardodej Z.Biotransformation of ethyl benzene, styrene, and alpha-methyl styrene in man.Am Ind Hyg Assoc J1970;31:206-9

[133]

Barr DB,Caudill SP,Needham LL.Urinary creatinine concentrations in the U.S. population: implications for urinary biologic monitoring measurements.Environ Health Perspect2005;113:192-200 PMCID:PMC1277864

[134]

Alwis KU,Britt AS,Ashley DL.Simultaneous analysis of 28 urinary VOC metabolites using Ultra High Performance Liquid Chromatography coupled with electrospray ionization tandem mass spectrometry (UPLC-ESI/MSMS).Anal Chim Acta2012;750:152-60

[135]

Centers for Disease Control and Prevention (CDC). Fourth National Report on Human Exposure to Environmental Chemicals Updated Tables, March 2021, Volume One: NHANES 1999-2010. 2021. Available from: https://www.cdc.gov/exposurereport/. [Last accessed on 9 Nov 2022]

[136]

Capella KM,Geldner N.Ethylbenzene and styrene exposure in the United States based on urinary mandelic acid and phenylglyoxylic acid: NHANES 2005-2006 and 2011-2012.Environ Res2019;171:101-10 PMCID:PMC6382531

[137]

Jain RB.Levels of selected urinary metabolites of volatile organic compounds among children aged 6-11 years.Environ Res2015;142:461-70

[138]

Jain RB.Levels of selected urinary metabolites of volatile organic compounds in a representative sample of US adolescents.Toxicol Environ Chem2016;98:977-90

[139]

Centers for Disease Control and Prevention (CDC). What’s New. Last Modified August 15, 2017. Accessed August 2017. Available from: https://www.cdc.gov/nchs/nhanes/new_nhanes.htm. [Last accessed on 9 Nov 2022]

[140]

Jain RB.Distributions of selected urinary metabolites of volatile organic compounds by age, gender, race/ethnicity, and smoking status in a representative sample of US adults.Environ Toxicol Pharmacol2015;40:471-9

[141]

Boyle E,Wright D,Alwis K. Assessment of exposure to VOCs among pregnant women in the National Children’s Study. Int J Env Res Public Health 2016;13:376. Available from: http://www.mdpi.com/1660-4601/13/4/376. [Last accessed on 9 Nov 2022]

[142]

De Jesús VR,Zhang L.Urinary biomarkers of exposure to volatile organic compounds from the population assessment of tobacco and health study wave 1 (2013-2014).Int J Environ Res Public Health2020;17:5408 PMCID:PMC7432690

[143]

Cattaneo A,Iodice S.Environmental and biological monitoring of personal exposure to air pollutants of adult people living in a metropolitan area.Sci Total Environ2021;767:144916

[144]

Konkle SL,Taylor KC,Bhatnagar A.National secular trends in ambient air volatile organic compound levels and biomarkers of exposure in the United States.Environ Res2020;182:108991 PMCID:PMC7294699

[145]

Fisher J,Bankston L,Gearhart J.Lactational transfer of volatile chemicals in breast milk.Am Ind Hyg Assoc J1997;58:425-31

[146]

Needham LL.Analytic considerations for measuring environmental chemicals in breast milk.Environ Health Perspect2002;110:A317-A24 PMCID:PMC1240885

[147]

Kim SR,Buckley TJ.Volatile organic compounds in human milk: methods and measurements.Environ Sci Technol2007;41:1662-7

[148]

U.S. Environmental Protection Agency (USEPA). Acquisition and Chemical Analysis of Mother’s Milk for Selected Toxic Substances. Washington, D.C.; 1980.

[149]

Pellizzari ED,Harris BSr,Whitaker DA.Purgeable organic compounds in mother’s milk.Bull Environ Contam Toxicol1982;28:322-8

[150]

Blount BC,Chambers DM,Squibb KS.Methodology for collecting, storing, and analyzing human milk for volatile organic compounds.J Environ Monit2010;12:1265-73

[151]

Hashimoto H,Hori H.Expert Division of Occupational Hygiene & ErgonomicsThe Japan Society for Occupational HealthThe Committee for Personal Exposure MonitoringGuidelines for personal exposure monitoring of chemicals: part IV.J Occup Health2018;60:103-10

[152]

U.S. Environmental Protection Agency (USEPA). Final Risk Evaluation for Methylene Chloride (Dichloromethane, DCM): DCM Supplemental File: Supplemental Information on Releases and Occupational Exposure Assessment. Washington, DC; 2020. Available from: https://www.epa.gov/sites/default/files/2020-06/documents/15_mecl_supplemental_information_on_releases_and_occupational_exposure_assessment_public.pdf. [Last accessed on 9 Nov 2022]

[153]

Hewett P.A comparison of several methods for analyzing censored data.Ann Occup Hyg2007;51:611-32

[154]

U.S. Environmental Protection Agency (USEPA). Guidelines for the Statistical Analysis of Occupational Exposure Data. Office of Pollution Prevention and Toxics. Washington, D.C.; 1994. Available from: https://www.epa.gov/tsca-screening-tools/guidelines-statistical-analysis-occupational-exposure-data. [Last accessed on 9 Nov 2022]

[155]

U.S. Environmental Protection Agency (USEPA). ProUCL Version 5.1 Technical Guide: Statistical Software for Environmental Applications for Data Sets with and without Nondetect Observations. Washington, DC; 2010. Available from: https://www.epa.gov/sites/production/files/2016-05/documents/proucl_5.1_user-guide.pdf. [Last accessed on 9 Nov 2022]

[156]

Lipiro DJ,Haberlein RA. Impact of Styrene PEL Reduction on Composites Manufacturers in California. 2004. Available from: https://styrene.org/wp-content/uploads/2018/05/SIRC-comments-to-ACGIH_053118-combined.pdf [Last accessed on 9 Nov 2022]

[157]

Zhou XH.Estimating the mean value of occupational exposures.Am Ind Hyg Assoc J1998;59:785-8

[158]

U.S. Environmental Protection Agency (USEPA). Calculating Upper Confidence Limits for Exposure Point Concentrations at Hazardous Waste Sites. Available from: https://nepis.epa.gov/Exe/ZyPDF.cgi/P100CYCE.PDF?Dockey=P100CYCE.PDF [Last accessed on 9 Nov 2022]

[159]

U.S. Environmental Protection Agency (USEPA). Human health evaluation manual, supplemental guidance: update of standard default exposure factors. Available from: https://www.epa.gov/sites/default/files/2015-11/documents/oswer_directive_9200.1-120_exposurefactors_corrected2.pdf [Last accessed on 9 Nov 2022]

[160]

U.S. Environmental Protection Agency (USEPA). 2017 National Emissions Inventory (NEI) Data (January 2021 version). Available from: https://www.epa.gov/air-emissions-inventories/2017-national-emissions-inventory-nei-data#datas [Last accessed on 9 Nov 2022]

[161]

U.S. Environmental Protection Agency (USEPA). Guidance on Selecting Age Groups for Monitoring and Assessing Childhood Exposures to Environmental Contaminants. Washington, D.C.; 2005. Available from: https://www.epa.gov/risk/guidance-selecting-age-groups-monitoring-and-assessing-childhood-exposures-environmental [Last accessed on 9 Nov 2022]

[162]

Bowman S,Carlson J,Lin B-H. Retail Food Commodity Intakes: Mean Amounts of Retail Commodities per Individual, 2007-08. Available from: https://www.ars.usda.gov/ARSUserFiles/80400530/pdf/ficrcd/ficrcd_intake_tables_2007_08.pdf [Last accessed on 9 Nov 2022]

[163]

Cao XL,Pelletier L.Styrene in foods and dietary exposure estimates.Food Addit Contam Part A Chem Anal Control Expo Risk Assess2018;35:2045-51

[164]

Banton M,Collins J,Gelbke H-P.Evaluation of potential health effects associated with occupational and environmental exposure to styrene-an update.J Toxicol Environ Health Part B2019;22:1-130

[165]

U.S. Environmental Protection Agency (USEPA). CompTox chemicals dashboard - Ethylbenzene 100-41-4 | DTXSID3020596. Available from: https://comptox.epa.gov/dashboard/chemical/details/DTXSID3020596 [Last accessed on 9 Nov 2022]

AI Summary AI Mindmap
PDF

49

Accesses

0

Citation

Detail

Sections
Recommended

AI思维导图

/