Characterizing and quantifying chemical ingredient use in consumer products between two separate databases and implications for environmental and human health exposure

Abstract

Assessing chemical exposure in home and personal care products (HPCPs) represents an important data need. Key challenges to the assessment are related to limited knowledge in quantifying and characterizing the weight-fraction inclusion level and functionality of chemicals in HPCPs. Publicly available tools have been developed to address these challenges, such as the Chemical and Products database (CPDat). This study aims to evaluate the relative performance of CPDat by comparing estimates of weight-fraction inclusion level and functionality to other relevant data sources. Specifically, estimates obtained from CPDat are evaluated and compared with estimates obtained from marketing analytic data, using Euromonitor Passport for 31 commonly used chemicals found in HPCPs. The results obtained from this exercise suggest relatively good agreement between each of the methods for 10 chemicals (ρ = 0.92; P-value =0.02). When considering all 31 chemical ingredients, however, the correlation observed is generally poor (ρ = 0.46; P-value = 0.1), which is attributed to differences in how the underlying data are obtained for each method. With an emphasis on obtaining data based on mining datasheets for individual products, the application of CPDat is suggested to be useful for higher tiers of assessment, with data obtained from marketing analytics providing valuable input to exposure-based screening models. The insight gained from this study can be used to help guide the appropriate use of data obtained from different sources within a tiered exposure assessment.

Keywords

Exposure / household and personal care products / chemical and products database / Euromonitor

References

[1] Cowan-Ellsberry CE.Refining aggregate exposure: example using parabens.Regul Toxicol Pharmacol2009;55:321-9

[2] Gouin T,Sparham C,Chowdhury N.Simulated use and wash-off release of decamethylcyclopentasiloxane used in anti-perspirants.Chemosphere2013;93:726-34

[3] Wannaz C,Kilgallon J,Jolliet O.A global framework to model spatial ecosystems exposure to home and personal care chemicals in Asia.Sci Total Environ2018;622-623:410-20

[4] Safford B,Barratt C.Use of an aggregate exposure model to estimate consumer exposure to fragrance ingredients in personal care and cosmetic products.Regul Toxicol Pharmacol2015;72:673-82

[5] Hodges JE,Vamshi R,Price OR.Estimating chemical emissions from home and personal care products in China.Environ Pollut2012;165:199-207

[6] Gouin T,Meyberg M,Rettinger K.Use of micro-plastic beads in cosmetic products in europe and their estimated emissions to the north sea environment.SOFW2015;141:40-6

[7] Gouin T,Lohmann R.A thermodynamic approach for assessing the environmental exposure of chemicals absorbed to microplastic.Environ Sci Technol2011;45:1466-72

[8] Zhu Y,Kilgallon J.Drivers of contaminant levels in surface water of China during 2000-2030: relative importance for illustrative home and personal care product chemicals.Environ Int2018;115:161-9

[9] Goldsmith MR,Brooks RD.Development of a consumer product ingredient database for chemical exposure screening and prioritization.Food Chem Toxicol2014;65:269-79

[10] Phillips KA,Grulke CM,Isaacs KK.High-throughput screening of chemicals as functional substitutes using structure-based classification models.Green Chem2017;19:1063-74 PMCID:PMC6260937

[11] Comiskey D,Barratt C.Novel database for exposure to fragrance ingredients in cosmetics and personal care products.Regul Toxicol Pharmacol2015;72:660-72

[12] The Soaps and Detergent Association. Exposure and risk screening methods for consumer product ingredients. 2005. Available from: https://www.cleaninginstitute.org/sites/default/files/research-pdfs/Exposure_and_Risk_Screening_Methods.pdf [Last accessed on 13 Jul 2022]

[13] Hall B,Safford B.European consumer exposure to cosmetic products, a framework for conducting population exposure assessments Part 2.Food Chem Toxicol2011;49:408-22

[14] Hall B,Safford B.European consumer exposure to cosmetic products, a framework for conducting population exposure assessments.Food Chem Toxicol2007;45:2097-108

[15] Loretz L,Barraj L.Exposure data for personal care products: hairspray, spray perfume, liquid foundation, shampoo, body wash, and solid antiperspirant.Food Chem Toxicol2006;44:2008-18

[16] Loretz LJ,Babcock L.Exposure data for cosmetic products: facial cleanser, hair conditioner, and eye shadow.Food Chem Toxicol2008;46:1516-24

[17] Whelan MJ,Williams RJ,Price OR.Estimating surface water concentrations of “down-the-drain” chemicals in China using a global model.Environ Pollut2012;165:233-40

[18] Gouin T,Price OR.Prioritising chemicals used in personal care products in China for environmental risk assessment: application of the RAIDAR model.Environ Pollut2012;165:208-14

[19] European Chemicals Bureau. Technical Guidance Document on Risk Assessment. European Commission; 2003. Available from: https://echa.europa.eu/documents/10162/987906/tgdpart2_2ed_en.pdf/138b7b71-a069-428e-9036-62f4300b752f [Last accessed on 13 Jul 2022]

[20] National Academies of Sciences Engineering Medicine. Exposure science in the 21st century: a vision and a strategy. Available from: https://nap.nationalacademies.org/catalog/13507/exposure-science-in-the-21st-century-a-vision-and-a [Last accessed on 13 Jul 2022]

[21] Hubal EA.Biologically relevant exposure science for 21st century toxicity testing.Toxicol Sci2009;111:226-32

[22] Dionisio KL,Goldsmith MR.Exploring consumer exposure pathways and patterns of use for chemicals in the environment.Toxicol Rep2015;2:228-37 PMCID:PMC5598258

[23] Phillips KA,Favela KA.Suspect screening analysis of chemicals in consumer products.Environ Sci Technol2018;52:3125-35 PMCID:PMC6168952

[24] Isaacs KK,Biryol D,Price PS.Consumer product chemical weight fractions from ingredient lists.J Expo Sci Environ Epidemiol2018;28:216-22 PMCID:PMC6082127

[25] Dionisio KL,Price PS.The chemical and products database, a resource for exposure-relevant data on chemicals in consumer products.Sci Data2018;5:180125 PMCID:PMC6038847

[26] Isaacs KK,Phillips K,Egeghy P.Establishing a system of consumer product use categories to support rapid modeling of human exposure.J Expo Sci Environ Epidemiol2020;30:171-83 PMCID:PMC7745729

[27] Williams AJ,Edwards J.The CompTox chemistry dashboard: a community data resource for environmental chemistry.J Cheminform2017;9:61 PMCID:PMC5705535

[28] Arnot JA,Webster E.Screening level risk assessment model for chemical fate and effects in the environment.Environ Sci Technol2006;40:2316-23

[29] Csiszar SA,Fantke P,Jolliet O.High-throughput exposure modeling to support prioritization of chemicals in personal care products.Chemosphere2016;163:490-8 PMCID:PMC7359637

[30] Dellarco M,Gaborek BJ.Using exposure bands for rapid decision making in the RISK21 tiered exposure assessment.Crit Rev Tox2017;47:317-41 PMCID:PMC6091571

[31] Wambaugh JF,Reif DM.High-throughput models for exposure-based chemical prioritization in the ExpoCast project.Environ Sci Technol2013;47:8479-88