Radiation-Grafted PBT Biomaterials for Enhanced Uric Acid Adsorption and Blood Compatibility

Abstract

The efficient removal of uric acid from blood via purification is a novel approach for the treatment of gout and hyperuricemia. In this study, a new polybutylene terephthalate (PBT) biomembrane with good uric acid adsorption capacity and desirable blood compatibility was prepared via radiation grafting of N-(4-vinylcarbonyloxyphenyl) acetamide (NVA) and acrylic acid (AA). The chemical structure and surface morphology of the modified membrane were characterized by Fourier transform infrared (FTIR) spectroscopy, X-ray photoelectron spectroscopy (XPS), and scanning electron microscopy (SEM). The wettability of the modified membrane was determined by measuring the water contact angle and water absorption rate. The results indicated that the modified membrane exhibited a maximum uric acid adsorption rate of (6.80±0.20)% with minimal impact on blood cell counts. This study provides a promising strategy for developing safe and efficient biomaterials for the treatment of gout and hyperuricemia.

Keywords

uric acid adsorption / radiation grafting / polybutylene terephthalate (PBT) / N-(4-vinylcarbonyloxyphenyl) acetamide (NVA) / blood cell count

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