Development of Electrochemical Sensor for Cefadroxil Antibiotic Based on Conductive Carbon Black Decorated with Tetrabutylammonium Tetrafluoroborate

Abstract

The development of analytical methods for antibiotic detection has become crucial for public health. In this research, a novel and simple electrochemical sensor for sensitive detection of cefadroxil(CFL) antibiotic was developed. The glassy carbon electrode(GCE) was coated with cheap conductive carbon black VXC-72R that was decorated with tetrabutylammonium tetrafluoroborate(TBABF₄), to construct the electrochemical sensor TBABF₄/VXC-72R/GCE. It was found that CFL exhibited a reduction peak at approximately 0.22 V on TBABF₄/VXC-72R/GCE. TBABF₄/VXC-72R/GCE showed a linear response to CFL in a concentration range of 0.3-10.0 μmol/L, with a detection limit of 0.2 μmol/L(a signal-to-noise ratio of 3). TBABF₄/VXC-72R/GCE showed good reproducibility, high storage stability and anti-interference performance. Analytical applications for CFL detection in real lake water, pharmaceutical tablet and fetal bovine serum samples were achieved.

Keywords

electrochemical sensor / conductive carbon black / tetrabutylammonium tetrafluoroborate(TBABF_4) / cefadroxil(CFL) antibiotic

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Funding

Research Foundation from National Innovation Center of Advanced Dyeing & Finishing Technology, China(2022GCJJ10)