Seaweeds’ nutraceutical and biomedical potential in cancer therapy: a concise review

João Cotas , Diana Pacheco , Ana M. M. Gonçalves , Paulo Silva , Loïc G. Carvalho , Leonel Pereira

Journal of Cancer Metastasis and Treatment ›› 2021, Vol. 7 : 13

PDF
Journal of Cancer Metastasis and Treatment ›› 2021, Vol. 7:13 DOI: 10.20517/2394-4722.2020.134
Review
review-article

Seaweeds’ nutraceutical and biomedical potential in cancer therapy: a concise review

Author information +
History +
PDF

Abstract

Seaweeds have been a food source since ancient times (600 BC) and are still widely used in Asia, mainly in traditional Chinese medicine and Japanese folk medicine. Nowadays, seaweed compounds and extracts have been gaining interest from the biomedical and pharmaceutical market sectors. Seaweeds have been referenced as feasible solutions in finding new potential compounds and therapies in prevention, control, and reduction of cancer development due to the multirole of some bioactive components (e.g, phenolic compounds and sulphated polysaccharides). Moreover, seaweeds are rich in important health-promoting molecules [such as poly and highly unsaturated fatty acids (PUFAs and HUFAs), essential amino acids, vitamins, and dietary fibers] and minerals (calcium, iron, iodine, magnesium, phosphorus, potassium, zinc, copper, manganese, selenium, and fluoride). In this review, the potential therapeutic effects of seaweed in the prevention and treatment of cancer are approached, as well as nutraceutical properties of seaweed to promote cell homeostasis.

Keywords

Seaweed compounds / nutraceutical / bioactive molecules / cancer prevention / cancer treatment

Cite this article

Download citation ▾
João Cotas, Diana Pacheco, Ana M. M. Gonçalves, Paulo Silva, Loïc G. Carvalho, Leonel Pereira. Seaweeds’ nutraceutical and biomedical potential in cancer therapy: a concise review. Journal of Cancer Metastasis and Treatment, 2021, 7: 13 DOI:10.20517/2394-4722.2020.134

登录浏览全文

4963

注册一个新账户 忘记密码

References

[1]

Sheikh I,Tuli HS,Sankhyan A.Cancer Chemoprevention by Flavonoids, Dietary Polyphenols and Terpenoids..Biointerface Res Appl Chem2020;11:8502-37

[2]

Vignesh S,Arthur Jam R.Marine Drugs: Implication and Future Studies..Int J Pharmacol2010;7:22-30

[3]

King RJB.Cancer biology.2006;Harlow, Essex, UKPearson Prentice Hall

[4]

Ruan BF,Lin MX.A Review of the Components of Seaweeds as Potential Candidates in Cancer Therapy..Anticancer Agents Med Chem2018;18:354-66

[5]

Bray F,Soerjomataram I,Torre LA.Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries..CA Cancer J Clin2018;68:394-424

[6]

Brown EM,Magee PJ.Seaweed and human health..Nutr Rev2014;72:205-16

[7]

Cotas J,Afonso MB,Pereira L.Antitumour Potential of Gigartina pistillata Carrageenans against Colorectal Cancer Stem Cell-Enriched Tumourspheres..Mar Drugs2020;18:50 PMCID:PMC7024308

[8]

Parkin DM,Ferlay J.Global cancer statistics, 2002..CA Cancer J Clin2005;55:74-108

[9]

Gersten O.The Cancer Transition in Japan since 1951..DemRes2002;7:271-306

[10]

Maule M.Cancer transition and priorities for cancer control..Lancet Oncol2012;13:745-6

[11]

Chinnababu B,Sankara Rao P.Isolation, semi-synthesis and bio-evaluation of spatane derivatives from the brown algae Stoechospermum marginatum..Bioorg Med Chem Lett2015;25:2479-83

[12]

Déléris P,Bard J.Seaweeds in Human Health. Seaweed in Health and Disease Prevention.2016;Elsevier319-67

[13]

Kolb N,Milanović N.Evaluation of Marine Algae Wakame (Undaria pinnatifida) and Kombu (Laminaria digitata japonica) as Food Supplements..Food Technol Biotechnol2004;42:57-61

[14]

Taboada MC,Miguez MI.Nutritional value of the marine algae wakame (Undaria pinnatifida) and nori (Porphyra purpurea) as food supplements..J Appl Phycol2013;25:1271-6

[15]

Pereira L.Seaweeds as source of bioactive substances and skin care therapy-Cosmeceuticals, algotheraphy, and thalassotherapy..Cosmetics2018;5:68

[16]

García-Poza S,Cotas C.The Evolution Road of Seaweed Aquaculture: Cultivation Technologies and the Industry 4.0..Int J Environ Res Public Health2020;17:6528 PMCID:PMC7560192

[17]

Ruperez P.Mineral content of edible marine seaweeds..Food Chem2002;79:23-6

[18]

Wali AF,Rasool S.Natural products against cancer: Review on phytochemicals from marine sources in preventing cancer..Saudi Pharm J2019;27:767-77 PMCID:PMC6733955

[19]

Leandro A,Gonçalves AMM.Diverse Applications of Marine Macroalgae..Mar Drugs2019;18:17 PMCID:PMC7024196

[20]

Kim SK.Handbook of Marine Macroalgae.2011;Chichester, UKJohn Wiley & Sons, Ltd

[21]

Francavilla M,Monteleone M.The red seaweed Gracilaria gracilis as a multi products source..Mar Drugs2013;11:3754-76 PMCID:PMC3826134

[22]

Giordano M,Raven JA.CO2 concentrating mechanisms in algae: mechanisms, environmental modulation, and evolution..Annu Rev Plant Biol2005;56:99-131

[23]

Rodrigues D,Pereira L.Chemical composition of red, brown and green macroalgae from Buarcos bay in Central West Coast of Portugal..Food Chem2015;183:197-207

[24]

Shannon E.Seaweeds as nutraceuticals for health and nutrition..Phycologia2019;58:563-77

[25]

Nunes N,Ferraz S,Pinheiro de Carvalho MAA.Nutraceutical potential of Asparagopsis taxiformis (Delile) Trevisan extracts and assessment of a downstream purification strategy..Heliyon2018;4:e00957

[26]

Pereira L.Edible Seaweeds of the World.2016;Boca Raton, FL, USACRC Press

[27]

Rajapakse N.Nutritional and Digestive Health Benefits of Seaweed. Marine Medicinal Foods - Implications and Applications, Macro and Microalgae.2011;Elsevier17-28

[28]

Mišurcová L,Orsavová J.Seaweed Minerals as Nutraceuticals. Marine Medicinal Foods - Implications and Applications, Macro and Microalgae.2011;Elsevier371-90

[29]

Černá M.Kim SK.Seaweed proteins and amino acids as nutraceuticals..Advances in food and nutrition research.2011;San DiegoAcademic Press297-312

[30]

Macartain P,Brooks M,Rowland IR.Nutritional Value of Edible Seaweeds..Nutr Rev2007;65:535-43

[31]

Ganesan AR,Rajauria G.Seaweed nutraceuticals and their therapeutic role in disease prevention..Food Sci Hum Wellness2019;8:252-63

[32]

Tanna B.Metabolites Unravel Nutraceutical Potential of Edible Seaweeds: An Emerging Source of Functional Food..Compr Rev Food Sci Food Saf2018;17:1613-24

[33]

Lopes G,Valentão P.Hernández-ledesma B.Sterols in Algae and Health..Bioactive Compounds from Marine Foods.2013;ChichesterJohn Wiley & Sons Ltd173-91

[34]

Alves C,Pinteus S.From Marine Origin to Therapeutics: The Antitumor Potential of Marine Algae-Derived Compounds..Front Pharmacol2018;9:777 PMCID:PMC6089330

[35]

Leandro A,Cotas J,Pereira L.Seaweed’s Bioactive Candidate Compounds to Food Industry and Global Food Security..Life (Basel)2020;10:140 PMCID:PMC7459772

[36]

Moon C,Kim JC.Protective effect of phlorotannin components phloroglucinol and eckol on radiation-induced intestinal injury in mice..Phytother Res2008;22:238-42

[37]

Park E,Yun JS.Dieckol rescues mice from lethal irradiation by accelerating hemopoiesis and curtailing immunosuppression..Int J Radiat Biol2010;86:848-59

[38]

Zhang R,Piao MJ.Eckol protects V79-4 lung fibroblast cells against gamma-ray radiation-induced apoptosis via the scavenging of reactive oxygen species and inhibiting of the c-Jun NH(2)-terminal kinase pathway..Eur J Pharmacol2008;591:114-23

[39]

Kang KA,Lee KH.Protective effect of triphlorethol-A from Ecklonia cava against ionizing radiation in vitro..J Radiat Res2006;47:61-8

[40]

Wang Z,Dong M,Cai Y.The anticancer effects and mechanisms of fucoxanthin combined with other drugs..J Cancer Res Clin Oncol2019;145:293-301

[41]

Gutiérrez-Rodríguez AG,Olivares-Bañuelos T.Anticancer activity of seaweeds..Drug Discov Today2018;23:434-47

[42]

Jiang J.Seaweeds and Cancer Prevention. Bioactive Seaweeds for Food Applications.2018;Elsevier269-90

[43]

Rocha DHA,Pinto DCGA.Seaweed Secondary Metabolites In Vitro and In Vivo Anticancer Activity..Mar Drugs2018;16:410 PMCID:PMC6266495

[44]

Ismail MM,El-Sheekh MM.Therapeutic Uses of Red Macroalgae..Molecules2020;25:4411 PMCID:PMC7583832

[45]

Murphy C,Worthington J.The potential of seaweed as a source of drugs for use in cancer chemotherapy..J Appl Phycol2014;26:2211-64

[46]

Kumar CS,Suresh P V..Seaweeds as a source of nutritionally beneficial compounds - a review..J Food Sci Technol2008;45:1-13

[47]

Cherry P,Magee PJ,Allsopp PJ.Risks and benefits of consuming edible seaweeds..Nutr Rev2019;77:307-29 PMCID:PMC6551690

[48]

Ferdouse F,Smith R,Yang Z.The global status of seaweed production, trade and utilization..FAO Globefish Res Program2018;124:120

[49]

Babahan I,Mehr H.T. Oliveira M,Fernandes-silva A.Major Natural Vegetation in Coastal and Marine Wetlands: Edible Seaweeds..Plant Communities and Their Environment.2020;IntechOpen

[50]

Novaczek I.Sea vegetable recipes for the Pacific Islands.2001;The University of the South Pacific

[51]

Unidade de Bioquímica M. Seaweed Recipes. 2020. Available from https://www.ubqmadeira.com/en/category/receitas/. [Last accessed on 5 Mar 2021]

[52]

Pacheco D,Cotas J,Neto JM.Invasive Seaweeds in the Iberian Peninsula: A Contribution for Food Supply..Mar Drugs2020;18:560 PMCID:PMC7697577

[53]

Park Y,Oh JH,Kim J.Dietary patterns and colorectal cancer risk in a Korean population: A case-control study..Medicine (Baltimore)2016;95:e3759 PMCID:PMC4998300

[54]

Nelson SM,Nogueira LM.Diet and biliary tract cancer risk in Shanghai, China..PLoS One2017;12:e0173935 PMCID:PMC5348031

[55]

Jemal A,Center MM,Ward E.Global cancer statistics..CA Cancer J Clin2011;61:69-90

[56]

Ferlay J,Steliarova-Foucher E.Estimates of cancer incidence and mortality in Europe in 2008..Eur J Cancer2010;46:765-81

[57]

Drewnowski A.The nutrition transition: new trends in the global diet..Nutr Rev1997;55:31-43

[58]

Wahlqvist M,Crotty P,Harvey P.Health and nutritional needs in the western pacific: culturally related areas which may be addressed by FBDGs. In: WHO Regional Office for the Western Pacific, editor. Development of food-based dietary guidelines for the Western Pacific region.1999;WHO Region. Manila, PhilippinesWorld Health Organization19-31

[59]

Iso H.Nutrition and disease in the Japan Collaborative Cohort Study for Evaluation of Cancer (JACC)..Asian Pac J Cancer Prev.2007;8 Suppl:35-80

[60]

Sá Monteiro M,Holdt S.Analysis and Risk Assessment of Seaweed..EFSA J2019;17:e170915 PMCID:PMC7015483

[61]

Ownsworth E,Ottley CJ.Tracing the natural and anthropogenic influence on the trace elemental chemistry of estuarine macroalgae and the implications for human consumption..Sci Total Environ2019;685:259-72

[62]

Teas J,Kurzer MS,Hurley TG.Seaweed and soy: companion foods in Asian cuisine and their effects on thyroid function in American women..J Med Food2007;10:90-100

[63]

Fleurence J.Seaweed proteins..Trends Food Sci Technol1999;10:25-8

[64]

Ramu Ganesan A,Shanmugam M.A comparison of nutritional value of underexploited edible seaweeds with recommended dietary allowances..J King Saud Univ - Sci2020;32:1206-11

[65]

Kalasariya H.S.,Pandya K.Y.,Brahmbhatt NH.A review on nutritional facets of seaweeds..Int J Chem Sci Tech2016;1:27-32

[66]

Syad AN,Kasi PD.Seaweeds as nutritional supplements: Analysis of nutritional profile, physicochemical properties and proximate composition of G. acerosa and S. wightii..Biomed Prev Nutr2013;3:139-44

[67]

Balagopal P,Patton N.Lifestyle-only intervention attenuates the inflammatory state associated with obesity: a randomized controlled study in adolescents..J Pediatr2005;146:342-8

[68]

Wong K.Nutritional evaluation of some subtropical red and green seaweeds..Food Chem2000;71:475-82

[69]

Klop B,Cabezas MC.Dyslipidemia in obesity: mechanisms and potential targets..Nutrients2013;5:1218-40 PMCID:PMC3705344

[70]

Al-Khalaifah H.Modulatory Effect of Dietary Polyunsaturated Fatty Acids on Immunity, Represented by Phagocytic Activity..Front Vet Sci2020;7:569939 PMCID:PMC7536543

[71]

Patarra RF,Neto AI,Baptista J.Nutritional value of selected macroalgae..J Appl Phycol2011;23:205-8

[72]

Matsumura Y.Nutrition trends in Japan..Asia Pac J Clin Nutr2001;10:S40-7

[73]

Murai U,Sata M.Seaweed intake and risk of cardiovascular disease: the Japan Public Health Center-based Prospective (JPHC) Study..Am J Clin Nutr2019;110:1449-55

[74]

Bhutta Z.Protein Deficiency. Encyclopedia of Human Nutrition.2013;Elsevier111-5

[75]

Heymsfield SB,Baier L.Hyperphagia: current concepts and future directions proceedings of the 2nd international conference on hyperphagia..Obesity (Silver Spring).2014;22 Suppl 1:S1-S17 PMCID:PMC4159941

[76]

Rosenbaum M.Adaptive thermogenesis in humans..Int J Obes (Lond).2010;34 Suppl 1:S47-55 PMCID:PMC3673773

[77]

Madhusudan C,Rahul K.Seaweeds: A Diet with Nutritional, Medicinal and Industrial Value..Res J Med Plant2011;5:153-7

[78]

Guo F,Cui Y,Niu K.Dietary seaweed intake and depressive symptoms in Japanese adults: a prospective cohort study..Nutr J2019;18:58 PMCID:PMC6781346

[79]

Machado M,Pimentel FB,Alves RC.Amino Acid Profile and Protein Quality Assessment of Macroalgae Produced in an Integrated Multi-Trophic Aquaculture System..Foods2020;9:1382 PMCID:PMC7600167

[80]

Percival E.Photosynthetic studies on Ulva lactuca..Phytochemistry1972;11:1967-72

[81]

Kadam SU,O’donnell CP.Extraction, structure and biofunctional activities of laminarin from brown algae..Int J Food Sci Technol2015;50:24-31

[82]

Devillé C,Forget P,Peulen O.Laminarin in the dietary fibre concept..J Sci Food Agric2004;84:1030-8

[83]

Valado A,Caseiro A.Effect of Carrageenans on Vegetable Jelly in Humans with Hypercholesterolemia..Mar Drugs2019;18:19 PMCID:PMC7024328

[84]

Cardoso I,Rodrigues A,Osório N.Extraction and Analysis of Compounds with Antibacterial Potential from the Red Alga Grateloupia turuturu..JMSE2019;7:220

[85]

Zhang Z,Wang J,Zhang H.Regioselective syntheses of sulfated porphyrans from Porphyra haitanensis and their antioxidant and anticoagulant activities in vitro..Carbohydrate Polymers2010;79:1124-9

[86]

Zargarzadeh M,Custódio CA.Biomedical applications of laminarin..Carbohydr Polym2020;232:115774

[87]

Sony NM,Hossain MS,Yokoyama S.The effect of dietary fucoidan on growth, immune functions, blood characteristics and oxidative stress resistance of juvenile red sea bream, Pagrus major..Fish Physiol Biochem2019;45:439-54

[88]

Cui H,Liu J.Effects of a highly purified fucoidan from Undaria pinnatifida on growth performance and intestine health status of gibel carp Carassius auratus gibelio..Aquacult Nutr2019;26:47-59

[89]

Nagamine T,Tomioka S,Nakajima K.Intestinal absorption of fucoidan extracted from the brown seaweed, Cladosiphon okamuranus..Mar Drugs2014;13:48-64 PMCID:PMC4306924

[90]

Zhao X,Hu J.Antithrombotic activity of oral administered low molecular weight fucoidan from Laminaria Japonica..Thromb Res2016;144:46-52

[91]

Wu SY,Hsieh-Chih-Tsai.Radioprotective effect of self-assembled low molecular weight Fucoidan-Chitosan nanoparticles..Int J Pharm2020;579:119161

[92]

Brownlee IA,Pearson JP.Alginate as a source of dietary fiber..Crit Rev Food Sci Nutr2005;45:497-510

[93]

Teas J,Cone DL.The consumption of seaweed as a protective factor in the etiology of breast cancer: proof of principle..J Appl Phycol2013;25:771-9 PMCID:PMC3651528

[94]

Padayatty SJ,Wang Y.Vitamin C as an antioxidant: evaluation of its role in disease prevention..J Am Coll Nutr2003;22:18-35

[95]

Kong X,Du G.Vitamin A. Natural Small Molecule Drugs from Plants.2018;SingaporeSpringer627-31

[96]

Allen L,Dary O,Horton S.Guidelines on food fortification with micronutrients.2006;World Heal. Geneva, SwitzerlandWorld Health Organization Press

[97]

Mora JR,von Andrian UH.Vitamin effects on the immune system: vitamins A and D take centre stage..Nat Rev Immunol2008;8:685-98 PMCID:PMC2906676

[98]

Pereira L.Pomin VH.A review of the nutrient composition of selected edible seaweeds..Seaweed: Ecology, Nutrient Composition and Medicinal Uses.2011;Hauppauge, NY, USANova Science Publishers, Inc.15-47

[99]

Miyashita K,Hosokawa M.Chemical and nutritional characteristics of brown seaweed lipids: A review..J Funct Foods2013;5:1507-17

[100]

Watzl B,Möseneder J,Bub A.A 4-wk intervention with high intake of carotenoid-rich vegetables and fruit reduces plasma C-reactive protein in healthy, nonsmoking men..Am J Clin Nutr2005;82:1052-8

[101]

Stead SM.Rethinking marine resource governance for the United Nations Sustainable Development Goals..Curr Opin Environ Sustain2018;34:54-61

[102]

Vieira EF,Machado S.Seaweeds from the Portuguese coast as a source of proteinaceous material: Total and free amino acid composition profile..Food Chem2018;269:264-75

[103]

Maeda H,Hirao K.Effects of agar (kanten) diet on obese patients with impaired glucose tolerance and type 2 diabetes..Diabetes Obes Metab2005;7:40-6

[104]

Mysliwa-Kurdziel B.Phycobilins and Phycobiliproteins Used in Food Industry and Medicine..Mini Rev Med Chem2017;17:1173-93

[105]

Viera I,Roca M.Bioaccessibility of Marine Carotenoids..Mar Drugs2018;16:397 PMCID:PMC6213429

[106]

Galasso C,Sansone C.Carotenoids from Marine Organisms: Biological Functions and Industrial Applications..Antioxidants (Basel)2017;6:96 PMCID:PMC5745506

[107]

Boominathan M.Kim S-K.Seaweed Carotenoids for Cancer Therapeutics..Handbook of Anticancer Drugs from Marine Origin.2015;Cham, SwitzerlandSpringer International Publishing Switzerland185-203

[108]

Kotake-Nara E,Nagao A.Characterization of apoptosis induced by fucoxanthin in human promyelocytic leukemia cells..Biosci Biotechnol Biochem2005;69:224-7

[109]

Gupta S.Recent developments in the application of seaweeds or seaweed extracts as a means for enhancing the safety and quality attributes of foods..Innov Food Sci Emerg Technol2011;12:600-9

[110]

Peñalver R,Ros G,Pateiro M.Seaweeds as a Functional Ingredient for a Healthy Diet..Mar Drugs2020;18:301 PMCID:PMC7345263

[111]

Félix R,Félix C,Lemos MFL.Industry-Friendly Hydroethanolic Extraction Protocols for Grateloupia turuturu UV-Shielding and Antioxidant Compounds..Appl Sci2020;10:5304

[112]

Eriksen NT.Production of phycocyanin--a pigment with applications in biology, biotechnology, foods and medicine..Appl Microbiol Biotechnol2008;80:1-14

[113]

Stengel DB,Popper ZA.Algal chemodiversity and bioactivity: sources of natural variability and implications for commercial application..Biotechnol Adv2011;29:483-501

[114]

Nguyen HPT,Déléris P.Purification of R-phycoerythrin from a marine macroalga Gracilaria gracilis by anion-exchange chromatography..J Appl Phycol2020;32:553-61

[115]

Yu P,Wang G,Zhang Y.Purification and bioactivities of phycocyanin..Crit Rev Food Sci Nutr2017;57:3840-9

[116]

Pardhasaradhi BV V,Kumari AL,Khar A.Phycocyanin-mediated apoptosis in AK-5 tumor cells involves down-regulation of Bcl-2 and generation of ROS..Mol Cancer Ther2003;2:1165-70

[117]

Jaiswal P,Prasanna R.Cyanobacterial bioactive molecules--an overview of their toxic properties..Can J Microbiol2008;54:701-17

[118]

Li W,Pu Y.Phycobiliproteins: molecular structure, production, applications, and prospects..Biotechnol Adv2019;37:340-53

[119]

Reddy MC,Mahipal S.C-Phycocyanin, a selective cyclooxygenase-2 inhibitor, induces apoptosis in lipopolysaccharide-stimulated RAW 264.7 macrophages..Biochem Biophys Res Commun2003;304:385-92

[120]

Shih SR,Li YS,Chan EC.Inhibition of enterovirus 71-induced apoptosis by allophycocyanin isolated from a blue-green alga Spirulina platensis..J Med Virol2003;70:119-25

[121]

Nagaraj S,Rajaram M.Hepatoprotective and antioxidative effects of C-phycocyanin from Arthrospira maxima SAG 25780 in CCl4-induced hepatic damage rats..Biomed Prev Nutr2012;2:81-5

[122]

Di Tomo P,Ciavardelli D.β-Carotene and lycopene affect endothelial response to TNF-α reducing nitro-oxidative stress and interaction with monocytes..Mol Nutr Food Res2012;56:217-27

[123]

Gori T.Oxidative stress and endothelial dysfunction: therapeutic implications..Ann Med2011;43:259-72

[124]

Guedes AC,Malcata FX.Microalgae as sources of carotenoids..Mar Drugs2011;9:625-44 PMCID:PMC3124977

[125]

Gao S,Liu Z,Ronchi CF.Lutein and zeaxanthin supplementation reduces H2O2-induced oxidative damage in human lens epithelial cells..Mol Vis2011;17:3180-90 PMCID:PMC3244479

[126]

Christaki E,Giannenas I.Functional properties of carotenoids originating from algae..J Sci Food Agric2013;93:5-11

[127]

Parjikolaei BR,Eybye KL.Valuable Biomolecules from Nine North Atlantic Red Macroalgae: Amino Acids, Fatty Acids, Carotenoids, Minerals and Metals..Natural Resources2016;07:157-83

[128]

Audibert L,Blanc N,Gall EA.Phenolic compounds in the brown seaweed Ascophyllum nodosum: distribution and radical-scavenging activities..Phytochem Anal2010;21:399-405

[129]

Generalić Mekinić I,Šimat V,Čagalj M.Phenolic Content of Brown Algae (Pheophyceae) Species: Extraction, Identification, and Quantification..Biomolecules2019;9:244 PMCID:PMC6628088

[130]

Gómez-Guzmán M,Algieri F.Potential Role of Seaweed Polyphenols in Cardiovascular-Associated Disorders..Mar Drugs2018;16:250 PMCID:PMC6117645

[131]

Chen Y,Li Z.The anti-allergic activity of polyphenol extracted from five marine algae..J Ocean Univ China2015;14:681-4

[132]

Murray M,Ryan L.The Impact of a Single Dose of a Polyphenol-Rich Seaweed Extract on Postprandial Glycaemic Control in Healthy Adults: A Randomised Cross-Over Trial..Nutrients2018;10:270 PMCID:PMC5872688

[133]

Pangestuti R.Neuroprotective effects of marine algae..Mar Drugs2011;9:803-18 PMCID:PMC3111183

[134]

Holdt SL.Bioactive compounds in seaweed: functional food applications and legislation..J Appl Phycol2011;23:543-97

[135]

Liu M,Lin X.Bromophenols in marine algae and their bioactivities..Mar Drugs2011;9:1273-92 PMCID:PMC3148503

[136]

Thomas NV.Potential pharmacological applications of polyphenolic derivatives from marine brown algae..Environ Toxicol Pharmacol2011;32:325-35

[137]

Tanna B,Mishra A.Phenolic, flavonoid, and amino acid compositions reveal that selected tropical seaweeds have the potential to be functional food ingredients..J Food Process Preserv2019;43:

[138]

Nwosu F,Lund VA,Ross HA.Anti-proliferative and potential anti-diabetic effects of phenolic-rich extracts from edible marine algae..Food Chem2011;126:1006-12

[139]

Lopes G,Silva LR.Can phlorotannins purified extracts constitute a novel pharmacological alternative for microbial infections with associated inflammatory conditions?.PLoS One2012;7:e31145 PMCID:PMC3271118

[140]

Urquiaga I.Plant polyphenol antioxidants and oxidative stress..Biol Res2000;33:55-64

[141]

Pereira L.Therapeutic and Nutritional Uses of Algae.2018;Boca Raton, FL, USACRC Press

[142]

Ravikumar S,Suganthi P.Seaweeds as a source of lead compounds for the development of new antiplasmodial drugs from South East coast of India..Parasitol Res2011;109:47-52

[143]

Schultz JC,Appel HM.Hemingway RW.Antimicrobial Activity of Polyphenols Mediates Plant-Herbivore Interactions..Plant Polyphenols.1992;Boston, MA, USASpringer US621-37

[144]

Maqsood S,Shahidi F.Emerging role of phenolic compounds as natural food additives in fish and fish products..Crit Rev Food Sci Nutr2013;53:162-79

[145]

Panzella L.Natural Phenol Polymers: Recent Advances in Food and Health Applications..Antioxidants (Basel)2017;6:30 PMCID:PMC5488010

[146]

Wang T,Kristinsson HG.Inhibition of haemoglobin-mediated lipid oxidation in washed cod muscle and cod protein isolates by Fucus vesiculosus extract and fractions..Food Chem2010;123:321-30

[147]

Chakraborty K,Praveen NK.Antioxidant activities and phenolic contents of three red seaweeds (Division: Rhodophyta) harvested from the Gulf of Mannar of Peninsular India..J Food Sci Technol2015;52:1924-35 PMCID:PMC4375198

[148]

Xu T,Casabianca H.Rapid Screening of Chemical Compositions of Gracilaria dura and Hypnea mucisformis (Rhodophyta) from Corsican Lagoon..Intl J Phyto Natu Ingrd2015;2:8

[149]

Tomaz ACDA,Souza MDFVD.Analysis and characterization of methyl esters of fatty acids of some Gracilaria species..Biochem Syst Ecol2012;44:303-6

[150]

Santos SA,Freire CS,Rocha SM.Chlorophyta and Rhodophyta macroalgae: a source of health promoting phytochemicals..Food Chem2015;183:122-8

[151]

Oren A.Mycosporines and mycosporine-like amino acids: UV protectants or multipurpose secondary metabolites?.FEMS Microbiol Lett2007;269:1-10

[152]

De Flora S.Overview of mechanisms of cancer chemopreventive agents..Mutat Res2005;591:8-15

[153]

Lee SB,Song DG,Nho CW.Cancer chemopreventive effects of Korean seaweed extracts..Food Sci Biotechnol2008;17:613-22

[154]

Teas J.Dietary Seaweed and Breast Cancer: A Randomized Trial.2005;Columbia, SC, USA

[155]

Minami Y,Oikawa T.Associations of Japanese food intake with survival of stomach and colorectal cancer: A prospective patient cohort study..Cancer Sci2020;111:2558-69 PMCID:PMC7385343

[156]

Zhang X,Huang ZX.In vitro fermentation of Gracilaria lemaneiformis sulfated polysaccharides and its agaro-oligosaccharides by human fecal inocula and its impact on microbiota..Carbohydr Polym2020;234:115894

[157]

Zheng LX,Cheong KL.Current trends in marine algae polysaccharides: The digestive tract, microbial catabolism, and prebiotic potential..Int J Biol Macromol2020;151:344-54

[158]

Gurpilhares DB,Simas NK,Sette LD.Marine prebiotics: Polysaccharides and oligosaccharides obtained by using microbial enzymes..Food Chem2019;280:175-86

[159]

Scharlau D,Habermann N.Mechanisms of primary cancer prevention by butyrate and other products formed during gut flora-mediated fermentation of dietary fibre..Mutat Res2009;682:39-53

[160]

Chen HM,Wang JL.Decreased dietary fiber intake and structural alteration of gut microbiota in patients with advanced colorectal adenoma..Am J Clin Nutr2013;97:1044-52

[161]

Abreu MT.Gastrointestinal malignancy and the microbiome..Gastroenterology2014;146:1534-1546.e3 PMCID:PMC3995897

[162]

Song M,Meyerhardt JA.Fiber Intake and Survival After Colorectal Cancer Diagnosis..JAMA Oncol2018;4:71-9 PMCID:PMC5776713

[163]

Teas J.The dietary intake of Laminaria, a brown seaweed, and breast cancer prevention..Nutr Cancer1983;4:217-22

[164]

Funahashi H,Tanaka Y.Suppressive effect of iodine on DMBA-induced breast tumor growth in the rat..J Surg Oncol1996;61:209-13

[165]

Funahashi H,Tanaka Y.Wakame seaweed suppresses the proliferation of 7,12-dimethylbenz(a)-anthracene-induced mammary tumors in rats..Jpn J Cancer Res1999;90:922-7 PMCID:PMC5926170

[166]

Funahashi H,Mase T.Seaweed prevents breast cancer?.Jpn J Cancer Res2001;92:483-7 PMCID:PMC5926746

[167]

Cherry P,Strain CR.Prebiotics from Seaweeds: An Ocean of Opportunity?.Mar Drugs2019;17:327 PMCID:PMC6627129

[168]

Yang YJ,Kong G.A case-control study on seaweed consumption and the risk of breast cancer..Br J Nutr2010;103:1345-53

[169]

Lopez-Santamarina A,Mondragon ADC.Potential Use of Marine Seaweeds as Prebiotics: A Review..Molecules2020;25:1004 PMCID:PMC7070434

[170]

Cotas J,Pacheco D,Pereira L.A Comprehensive Review of the Nutraceutical and Therapeutic Applications of Red Seaweeds (Rhodophyta)..Life (Basel)2020;10:19 PMCID:PMC7151636

[171]

Cotas J,Monteiro P.Seaweed Phenolics: From Extraction to Applications..Mar Drugs2020;18:384 PMCID:PMC7460554

[172]

Pereira L.Pereira L.Introductory Chapter: Alginates - A General Overview..Alginates - Recent Uses of This Natural Polymer.2020;IntechOpen

[173]

Wang HD,Lee DJ.Potential biomedical applications of marine algae..Bioresour Technol2017;244:1407-15

[174]

Bilal M.Marine seaweed polysaccharides-based engineered cues for the modern biomedical sector..Mar Drugs2020;18:7 PMCID:PMC7024278

[175]

Sezer AD.Zilberman M.Fucoidan: A Versatile Biopolymer for Biomedical Applications..Active Implants and Scaffolds for Tissue Regeneration.2011;BerlinSpringer Berlin Heidelberg377-406

[176]

Liu L,Myers S.Towards a better understanding of medicinal uses of the brown seaweed Sargassum in Traditional Chinese Medicine: a phytochemical and pharmacological review..J Ethnopharmacol2012;142:591-619

[177]

McKim JM,Blakemore WR.Clarifying the confusion between poligeenan, degraded carrageenan, and carrageenan: A review of the chemistry, nomenclature, and in vivo toxicology by the oral route..Crit Rev Food Sci Nutr2019;59:3054-73

[178]

Pal A,Kumar A.Bioactive compounds and properties of seaweeds-a review..OALib2014;01:1-17

[179]

Silva TH,Ferreira BM.Materials of marine origin: a review on polymers and ceramics of biomedical interest..Int Mater Rev2013;57:276-306

[180]

Pereira L.Biological and therapeutic properties of the seaweed polysaccharides..Int Biol Rev2018;2:1-50

[181]

Pereira H,Figueiredo F.Polyunsaturated Fatty acids of marine macroalgae: potential for nutritional and pharmaceutical applications..Mar Drugs2012;10:1920-35 PMCID:PMC3475264

[182]

Huheihel M,Tal J.Activity of Porphyridium sp. polysaccharide against herpes simplex viruses in vitro and in vivo..J Biochem Biophys Methods2002;50:189-200

[183]

Palumbo MO,Miller WH Jr.Systemic cancer therapy: achievements and challenges that lie ahead..Front Pharmacol2013;4:57 PMCID:PMC3646247

[184]

Muniyan S,Datta K.Cardiovascular risks and toxicity - The Achilles heel of androgen deprivation therapy in prostate cancer patients..Biochim Biophys Acta Rev Cancer2020;1874:188383 PMCID:PMC7473503

[185]

Mayer AMS,Taglialatela-Scafati O.Marine pharmacology in 2012-2013: marine compounds with antibacterial, antidiabetic, antifungal, anti-inflammatory, antiprotozoal, antituberculosis, and antiviral activities; affecting the immune and nervous systems, and other miscellaneous mechanisms of action..Mar Drugs2017;15:273 PMCID:PMC5618412

[186]

Djulbegovic B,Soares HP.Treatment success in cancer: new cancer treatment successes identified in phase 3 randomized controlled trials conducted by the National Cancer Institute-sponsored cooperative oncology groups, 1955 to 2006..Arch Intern Med2008;168:632-42 PMCID:PMC2773511

[187]

Nass SJ, Levit LA, Gostin LO. The Value, Importance, and Oversight of Health Research. In: Nass SJ, Levit LA, Gosti LO, editors. Beyond the HIPAA Privacy Rule: Enhancing Privacy, Improving Health Through Research. Washington, D.C., USA: National Academies Press (US); 2009. Available from: https://www.ncbi.nlm.nih.gov/books/NBK9571/. [Last accessed on 28 Nov 2020]

[188]

Qi X,Qiu L,Liu M.Marine bromophenol bis(2,3-dibromo-4,5-dihydroxybenzyl) ether, represses angiogenesis in HUVEC cells and in zebrafish embryos via inhibiting the VEGF signal systems..Biomed Pharmacother2015;75:58-66

[189]

Liu M,Xiao L.Bis(2,3-dibromo-4,5-dihydroxybenzyl) ether, a marine algae derived bromophenol, inhibits the growth of Botrytis cinerea and interacts with DNA molecules..Mar Drugs2014;12:3838-51 PMCID:PMC4113801

[190]

Liu M,Wei J,Lin X.Marine bromophenol bis(2,3-dibromo-4,5-dihydroxybenzyl) ether, induces mitochondrial apoptosis in K562 cells and inhibits topoisomerase I in vitro..Toxicol Lett2012;211:126-34

[191]

Hanahan D.Hallmarks of cancer: the next generation..Cell2011;144:646-74

[192]

Pádua D,Gargiulo D.Bioactive compounds from brown seaweeds: Phloroglucinol, fucoxanthin and fucoidan as promising therapeutic agents against breast cancer..Phytochem Lett2015;14:91-8

[193]

AbuHammad S.Gene expression alterations in doxorubicin resistant MCF7 breast cancer cell line..Genomics2013;101:213-20

[194]

Shi Z,Chen Z.Overexpression of Survivin and XIAP in MDR cancer cells unrelated to P-glycoprotein..Oncol Rep2007;17:969-76

[195]

Tegze B,Haltrich I.Parallel evolution under chemotherapy pressure in 29 breast cancer cell lines results in dissimilar mechanisms of resistance..PLoS One2012;7:e30804 PMCID:PMC3271089

[196]

Yun CW,Lee SH.Therapeutic Application of Diverse Marine-derived Natural Products in Cancer Therapy..Anticancer Res2019;39:5261-84

[197]

Machana S,Barusrux S.Anticancer effect of the extracts from Polyalthia evecta against human hepatoma cell line (HepG2)..Asian Pac J Trop Biomed2012;2:368-74 PMCID:PMC3609308

[198]

In vitro antileishmanial, antibacterial, antifungal and anticancer activity of fucoidan from Undaria pinnatifida..Int J Biosci2017;11:219-27

[199]

Reyes ME,Salvo T,Letelier P.Brown Seaweed Fucoidan in Cancer: Implications in Metastasis and Drug Resistance..Mar Drugs2020;18:232 PMCID:PMC7281670

[200]

Eo HJ,Park GH.In Vitro Anticancer Activity of Phlorofucofuroeckol A via Upregulation of Activating Transcription Factor 3 against Human Colorectal Cancer Cells..Mar Drugs2016;14:69 PMCID:PMC4849073

[201]

Vizetto-Duarte C,Gangadhar KN.Isololiolide, a carotenoid metabolite isolated from the brown alga Cystoseira tamariscifolia, is cytotoxic and able to induce apoptosis in hepatocarcinoma cells through caspase-3 activation, decreased Bcl-2 levels, increased p53 expression and PARP cleavage..Phytomedicine2016;23:550-7

[202]

Kim RK,Hyun JW,Suh Y.Novel anticancer activity of phloroglucinol against breast cancer stem-like cells..Toxicol Appl Pharmacol2015;286:143-50

[203]

Prasedya ES,Kobayashi D.Carrageenan delays cell cycle progression in human cancer cells in vitro demonstrated by FUCCI imaging..BMC Complement Altern Med2016;16:270 PMCID:PMC4973075

[204]

Yu Q,Wang S.Antiangiogenic effects of GFP08, an agaran-type polysaccharide isolated from Grateloupia filicina..Glycobiology2012;22:1343-52

[205]

Cavas L,Yurdakoc K.Antiproliferative and newly attributed apoptotic activities from an invasive marine alga: Caulerpa racemosa var. cylindracea..J Exp Mar Bio Ecol2006;339:111-9

[206]

Liu Z,Yang Y.Anti-Cancer Activity of Porphyran and Carrageenan from Red Seaweeds..Molecules2019;24:4286 PMCID:PMC6930528

[207]

Catarino MD,Mateus N.Optimization of Phlorotannins Extraction from Fucus vesiculosus and Evaluation of Their Potential to Prevent Metabolic Disorders..Mar Drugs2019;17:162 PMCID:PMC6471631

[208]

Hussain SP,Harris CC.Radical causes of cancer..Nat Rev Cancer2003;3:276-85

[209]

Wijesekara I,Kim SK.Phlorotannins from Ecklonia cava (Phaeophyceae): biological activities and potential health benefits..Biofactors2010;36:408-14

[210]

Li Y,Li Y.Phlorotannins as bioactive agents from brown algae..Process Biochem2011;46:2219-24

[211]

Lijun H,Jiangong S,Chengkui Z.Isolation and pharmacological activities of bromophenols fromRhodomela confervoides..Chin J Ocean Limnol2005;23:226-9

[212]

Xu N,Yan X.Screening marine algae from China for their antitumor activities..J Appl Phycol2004;16:451-6

[213]

Shoemaker RH.The NCI60 human tumour cell line anticancer drug screen..Nat Rev Cancer2006;6:813-23

[214]

Sepantafar M,Mohammadi H.Engineered Hydrogels in Cancer Therapy and Diagnosis..Trends Biotechnol2017;35:1074-87

[215]

Topalian SL,Pardoll DM.Cancer immunotherapy comes of age..J Clin Oncol2011;29:4828-36 PMCID:PMC3967235

[216]

Reed SG,Fox CB.Key roles of adjuvants in modern vaccines..Nat Med2013;19:1597-608

[217]

Moyer MW.New adjuvants aim to give whooping cough vaccine a boost..Nat Med2012;18:991

[218]

Costa LS,Cordeiro SL.Biological activities of sulfated polysaccharides from tropical seaweeds..Biomed Pharmacother2010;64:21-8

[219]

Maruyama H,Iizuka M.The role of NK cells in antitumor activity of dietary fucoidan from Undaria pinnatifida sporophylls (Mekabu)..Planta Med2006;72:1415-7

[220]

Chen LM,Chen YA.Oligo-Fucoidan prevents IL-6 and CCL2 production and cooperates with p53 to suppress ATM signaling and tumor progression..Sci Rep2017;7:11864 PMCID:PMC5605496

[221]

Pan TJ,Zhang JW.Antimetastatic Effect of Fucoidan-Sargassum against Liver Cancer Cell Invadopodia Formation via Targeting Integrin αVβ3 and Mediating αVβ3/Src/E2F1 Signaling..J Cancer2019;10:4777-92 PMCID:PMC6775528

[222]

Luo M,Nie W.Antitumor and Adjuvant Activity of λ-carrageenan by Stimulating Immune Response in Cancer Immunotherapy..Sci Rep2015;5:11062 PMCID:PMC4476469

[223]

Song K,Zhang W.Laminarin promotes anti-cancer immunity by the maturation of dendritic cells..Oncotarget2017;8:38554-67 PMCID:PMC5503553

[224]

Sun J,Song B.Fucoidan inhibits CCL22 production through NF-κB pathway in M2 macrophages: a potential therapeutic strategy for cancer..Sci Rep2016;6:35855 PMCID:PMC5075786

[225]

Park HB,Zhang W.Polysaccharide from Codium fragile Induces Anti-Cancer Immunity by Activating Natural Killer Cells..Mar Drugs2020;18:626 PMCID:PMC7763488

[226]

Pawar VK,Sharma K.Improved chemotherapy against breast cancer through immunotherapeutic activity of fucoidan decorated electrostatically assembled nanoparticles bearing doxorubicin..Int J Biol Macromol2019;122:1100-14

[227]

Cunha L.Sulfated Seaweed Polysaccharides as Multifunctional Materials in Drug Delivery Applications..Mar Drugs2016;14:42 PMCID:PMC4820297

[228]

Adachi M.Evaluation of combined deactivators-supplemented agar medium (CDSAM) for recovery of dermatophytes from patients with tinea pedis..Med Mycol2007;45:347-9

[229]

Yew WW,Lui KS,Chau CH.Comparison of MB/BacT system and agar proportion method in drug susceptibility testing of Mycobacterium tuberculosis..Diagn Microbiol Infect Dis2001;39:229-32

[230]

Sathuvan M,Gajendiran M.κ-Carrageenan: An effective drug carrier to deliver curcumin in cancer cells and to induce apoptosis..Carbohydr Polym2017;160:184-93

[231]

Sezer AD,Hatipoğlu F,Baş AL.The use of fucosphere in the treatment of dermal burns in rabbits..Eur J Pharm Biopharm2008;69:189-98

[232]

Lai YH,Hsu CH,Chen SY.Development and Characterization of a Fucoidan-Based Drug Delivery System by Using Hydrophilic Anticancer Polysaccharides to Simultaneously Deliver Hydrophobic Anticancer Drugs..Biomolecules2020;10:970 PMCID:PMC7408464

[233]

Thakur SS,Suk JS,Rupenthal ID.Validation of hyaluronic acid-agar-based hydrogels as vitreous humor mimetics for in vitro drug and particle migration evaluations..Eur J Pharm Biopharm2020;148:118-25

[234]

Wu C,Hu F.Design of injectable agar-based composite hydrogel for multi-mode tumor therapy..Carbohydr Polym2018;180:112-21

[235]

Venkatesan J,Kim SK.Seaweed Polysaccharide-Based Nanoparticles: Preparation and Applications for Drug Delivery..Polymers (Basel)2016;8:30 PMCID:PMC6432598

[236]

Zhang C,Wang C.Cytotoxicity of liver targeted drug-loaded alginate nanoparticles..Sci China Ser B-Chem2009;52:1382-7

[237]

Zhang C,Liu T.Doxorubicin-loaded glycyrrhetinic acid-modified alginate nanoparticles for liver tumor chemotherapy..Biomaterials2012;33:2187-96

[238]

Roy D,Sumerlin BS.Future perspectives and recent advances in stimuli-responsive materials..Prog Polym Sci2010;35:278-301

[239]

Bouhadir KH,Mooney DJ.Hydrogels for combination delivery of antineoplastic agents..Biomaterials2001;22:2625-33

[240]

Chemoprotective Agents. Available from: https://chemoth.com/chemoprotective. [Last accessed on 15 Nov 2020]

[241]

Shin T,Hyun JW,Moon C.Antioxidant marine algae phlorotannins and radioprotection: a review of experimental evidence..Acta Histochem2014;116:669-74

[242]

Park E,Joo HG.Modulation of apoptosis of eckol against ionizing radiation in mice..Biochem Biophys Res Commun2008;372:792-7

[243]

Shibata T,Kawaguchi S,Hama Y.Antioxidant activities of phlorotannins isolated from Japanese Laminariaceae..J Appl Phycol2008;20:705-11

[244]

Besednova NN,Kuznetsova TA.Marine Algae Metabolites as Promising Therapeutics for the Prevention and Treatment of HIV/AIDS..Metabolites2019;9:87 PMCID:PMC6572556

[245]

Kim AR,Shin TS.Phlorofucofuroeckol A inhibits the LPS-stimulated iNOS and COX-2 expressions in macrophages via inhibition of NF-κB, Akt, and p38 MAPK..Toxicol In Vitro2011;25:1789-95

[246]

Chang MY,Shin HC.Protective effects of the seaweed phlorotannin polyphenolic compound dieckol on gentamicin-induced damage in auditory hair cells..Int J Pediatr Otorhinolaryngol2016;83:31-6

[247]

Liu EH,Wu Q,Li P.Anticancer agents derived from natural products..Mini Rev Med Chem2009;9:1547-55

[248]

van Weelden G,Okła K,Romano A.Fucoidan Structure and Activity in Relation to Anti-Cancer Mechanisms..Mar Drugs2019;17:32 PMCID:PMC6356449

[249]

Kwak JY.Fucoidan as a marine anticancer agent in preclinical development..Mar Drugs2014;12:851-70 PMCID:PMC3944519

[250]

Fletcher H,Ross A.The seasonal variation of fucoidan within three species of brown macroalgae..Algal Res2017;22:79-86

[251]

Riou D,Pinczon Du Sel D.Antitumor and antiproliferative effects of a fucan extracted from Ascophyllum nodosum against a non-small-cell bronchopulmonary carcinoma line..Anticancer Res1996;16:1213-8

[252]

Lin Y,Liu H,Xu S.The anti-cancer effects of fucoidan: a review of both in vivo and in vitro investigations..Cancer Cell Int2020;20:154 PMCID:PMC7206694

[253]

Tokita Y,Mochida H,Nagamine T.Development of a fucoidan-specific antibody and measurement of fucoidan in serum and urine by sandwich ELISA..Biosci Biotechnol Biochem2010;74:350-7

[254]

Lowenthal RM.Are seaweed-derived fucoidans possible future anti-cancer agents?.J Appl Phycol2015;27:2075-7

[255]

Tsai HL,Huang CW,Wang JY.Efficacy of Low-Molecular-Weight Fucoidan as a Supplemental Therapy in Metastatic Colorectal Cancer Patients: A Double-Blind Randomized Controlled Trial..Mar Drugs2017;15:122 PMCID:PMC5408268

[256]

Tocaciu S,Lowenthal RM.The Effect of Undaria pinnatifida Fucoidan on the Pharmacokinetics of Letrozole and Tamoxifen in Patients With Breast Cancer..Integr Cancer Ther2018;17:99-105 PMCID:PMC5950942

[257]

Ikeguchi M,Arai Y.Fucoidan reduces the toxicities of chemotherapy for patients with unresectable advanced or recurrent colorectal cancer..Oncol Lett2011;2:319-22 PMCID:PMC3410608

[258]

Scheuer PJ,Gravalos DG.US-6011010-A - Cytotoxic and antiviral compound.1997;

[259]

Suárez Y,Cuadrado A,Lafarga M.Kahalalide F, a new marine-derived compound, induces oncosis in human prostate and breast cancer cells..Mol Cancer Ther2003;2:863-72

[260]

Martín-Algarra S,Rubió J.Phase II study of weekly Kahalalide F in patients with advanced malignant melanoma..Eur J Cancer2009;45:732-5

[261]

Claudio F.An experimental contribution to the clinical use of an algal phytocolloid (Algasol T331) in oncology. Proceedings of the Fifth International Seaweed Symposium, Halifax, August 25-28, 1965.1966;Elsevier369

AI Summary AI Mindmap
PDF

40

Accesses

0

Citation

Detail

Sections
Recommended

AI思维导图

/