A new twist to neurotransmitter receptors and cancer

References

[1] Sudhof TC.Calcium control of neurotransmitter release..Cold Spring Harb Perspect Biol2012;4:a011353

[2] D'Souza MS.Neuroscience of nicotine for addiction medicine: novel targets for smoking cessation medications..Prog Brain Res2016;223:191-214

[3] Lefkowitz RJ.Seven transmembrane receptors: something old, something new..Acta Physiol (Oxf)2007;190:9-19

[4] Reuter H.Calcium channel modulation by beta-adrenergic neurotransmitters in the heart..Experientia1987;43:1173-5

[5] Yang Z,MacDougall DA,Deuchars J,Ponnambalam S,White E,Peers C.The Golgi apparatus is a functionally distinct Ca2+ store regulated by the PKA and Epac branches of the beta1-adrenergic signaling pathway..Sci Signal2015;8:ra101

[6] Grau M,Ramirez I.Interaction between adrenaline and epidermal growth factor in the control of liver glycogenolysis in mouse..Endocrinology1997;138:2601-9

[7] Schuller HM,Williams M.The tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone is a beta-adrenergic agonist and stimulates DNA synthesis in lung adenocarcinoma via beta-adrenergic receptor-mediated release of arachidonic acid..Cancer Res1999;59:4510-5

[8] Weddle DL,Williams M.Beta-adrenergic growth regulation of human cancer cell lines derived from pancreatic ductal carcinomas..Carcinogenesis2001;22:473-9

[9] Madden KS,Brown EB.beta-Adrenergic receptors (beta-AR) regulate VEGF and IL-6 production by divergent pathways in high beta-AR-expressing breast cancer cell lines..Breast Cancer Res Treat2011;130:747-58 PMCID:PMC3126869

[10] Ziegler MG.Sympathetic nerves and hypertension in stress, sleep apnea, and caregiving..Curr Opin Nephrol Hypertens2017;26:26-30

[11] McEwen BS.The neurobiology of stress: from serendipity to clinical relevance..Brain Res2000;886:172-89

[12] Sala F,Criado M.Nicotinic acetylcholine receptors of adrenal chromaffin cells..Acta Physiol (Oxf)2008;192:203-12

[13] Li YF,Freeling J.Specific subtypes of nicotinic cholinergic receptors involved in sympathetic and parasympathetic cardiovascular responses..Neurosci Lett2009;462:20-3 PMCID:PMC2745958

[14] Szentmiklosi AJ,Hegyi B,Magyar J,Nanasi PP.Chemistry, physiology, and pharmacology of beta-adrenergic mechanisms in the heart. Why are beta-blocker antiarrhythmics superior?.Curr Pharm Des2015;21:1030-41

[15] Ferguson SS.Beta-adrenoceptors as molecular targets in the treatment of hypertension..Can J Cardiol2014;30:S3-8

[16] Cameron AC,Touyz RM.Drug treatment of hypertension: focus on vascular health..Drugs2016;76:1529-50

[17] Fares H,O'Keefe JH.Amlodipine in hypertension: a first-line agent with efficacy for improving blood pressure and patient outcomes..Open Heart2016;3:e000473

[18] Schuller HM.Cell type specific, receptor-mediated modulation of growth kinetics in human lung cancer cell lines by nicotine and tobacco-related nitrosamines..Biochem Pharmacol1989;38:3439-42

[19] Maneckjee R.Opioid and nicotine receptors affect growth regulation of human lung cancer cell lines..Proc Natl Acad Sci U S A1990;87:3294-8 PMCID:PMC53886

[20] Cattaneo MG,Vicentini LM,Sher E.Nicotine stimulates a serotonergic autocrine loop in human small-cell lung carcinoma..Cancer Res1993;53:5566-8

[21] Schuller HM.Regulation of cell proliferation by beta-adrenergic receptors in a human lung adenocarcinoma cell line..Carcinogenesis1989;10:1753-5

[22] Park PG,Orloff M.Beta-adrenergic mitogenic signal transduction in peripheral lung adenocarcinoma: implications for individuals with preexisting chronic lung disease..Cancer Res1995;55:3504-8

[23] Schuller HM.Tobacco-specific carcinogenic nitrosamines. Ligands for nicotinic acetylcholine receptors in human lung cancer cells..Biochem Pharmacol1998;55:1377-84

[24] Arredondo J,Grando SA.Nicotinic receptors mediate tumorigenic action of tobacco-derived nitrosamines on immortalized oral epithelial cells..Cancer Biol Ther2006;5:511-7

[25] Askari MD,Schuller HM.The tobacco-specific carcinogen, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone stimulates proliferation of immortalized human pancreatic duct epithelia through beta-adrenergic transactivation of EGF receptors..J Cancer Res Clin Oncol2005;131:639-48

[26] Schuller HM.Neurotransmission and cancer: implications for prevention and therapy..Anticancer Drugs2008;19:655-71

[27] Schuller HM.Is cancer triggered by altered signalling of nicotinic acetylcholine receptors?.Nat Rev Cancer2009;9:195-205

[28] Tang J,Lu L.β-Adrenergic system, a backstage manipulator regulating tumour progression and drug target in cancer therapy..Semin Cancer Biol2013;23:533-42

[29] Chang A,Le CP,Sloan EK.Neural regulation of pancreatic cancer: a novel target for intervention..Cancers (Basel)2015;7:1292-312 PMCID:PMC4586771

[30] Cesario A,Nastrucci C.Is alpha7-nAChR a possible target for lung cancer and malignant pleural mesothelioma treatment?.Curr Drug Targets2012;13:688-94

[31] Wessler I.Acetylcholine beyond neurons: the non-neuronal cholinergic system in humans..Br J Pharmacol2008;154:1558-71 PMCID:PMC2518461

[32] Shin VY,Chu KM,Wong HP,Tai EK.Functional role of beta-adrenergic receptors in the mitogenic action of nicotine on gastric cancer cells..Toxicol Sci2007;96:21-9

[33] Wong HP,Lam EK,Wu WK.Nicotine promotes cell proliferation via alpha7-nicotinic acetylcholine receptor and catecholamine-synthesizing enzymes-mediated pathway in human colon adenocarcinoma HT-29 cells..Toxicol Appl Pharmacol2007;221:261-7

[34] Al-Wadei HA,Masi T.Chronic exposure to estrogen and the tobacco carcinogen NNK cooperatively modulates nicotinic receptors in small airway epithelial cells..Lung Cancer2010;69:33-9

[35] Al-Wadei HA,Schuller HM.Cooperative regulation of non-small cell lung carcinoma by nicotinic and beta-adrenergic receptors: a novel target for intervention..PLoS One2012;7:e29915

[36] Al-Wadei MH,Schuller HM.Pancreatic cancer cells and normal pancreatic duct epithelial cells express an autocrine catecholamine loop that is activated by nicotinic acetylcholine receptors alpha3, alpha5, and alpha7..Mol Cancer Res2012;10:239-49 PMCID:PMC3340883

[37] Sun H,He B,Ying H,Liu X.Different effects of the three polymorphisms on 15q25.1 onlung cancer risk: evidence from published literatures..J Cancer Res Ther2016;12:12-9

[38] Xu ZW,Dong ZZ,Cao C.CHRNA5 rs16969968 polymorphism association with risk of lung cancer -- evidence from 17,962 lung cancer cases and 77,216 control subjects..Asian Pac J Cancer Prev2015;16:6685-90

[39] Zhou W,Wang H,Feng T,Kang L,Chen C.CHRNA3 genetic polymorphism and the risk of lung cancer in the Chinese Han smoking population..Tumour Biol2015;36:4987-92

[40] Wenjuan Y,Ceng Y.Association of single nucleotide polymorphisms of beta2-adrenergic receptor gene with clinicopathological features of pancreatic carcinoma..Acta Histochem2013;115:198-203

[41] Al-Wadei HA,Ullah MF,Brody JR.Social stress promotes and gamma-aminobutyric acid inhibits tumor growth in mouse models of non-small cell lung cancer..Cancer Prev Res (Phila)2012;5:189-96 PMCID:PMC3320046

[42] Schuller HM,Ullah MF.Regulation of pancreatic cancer by neuropsychological stress responses: a novel target for intervention..Carcinogenesis2012;33:191-6 PMCID:PMC3276326

[43] Sood AK,Kamat AA,Han L,Li Y,Lutgendorf S.Stress hormone-mediated invasion of ovarian cancer cells..Clin Cancer Res2006;12:369-75 PMCID:PMC3141061

[44] Palm D,Niggemann B,Masur K,Entschladen F.The norepinephrine-driven metastasis development of PC-3 human prostate cancer cells in BALB/c nude mice is inhibited by beta-blockers..Int J Cancer2006;118:2744-9

[45] Huang XY,Yuan Z,Zheng Q.Norepinephrine stimulates pancreatic cancer cell proliferation, migration and invasion via beta-adrenergic receptor-dependent activation of P38/MAPK pathway..Hepatogastroenterology2012;59:889-93

[46] Hara MR,Caron MG.Pharmacological blockade of a beta(2)AR-beta-arrestin-1 signaling cascade prevents the accumulation of DNA damage in a behavioral stress model..Cell Cycle2013;12:219-24 PMCID:PMC3575451

[47] Hu W,Czeh B,Zhang W.Stress impairs GABAergic network function in the hippocampus by activating nongenomic glucocorticoid receptors and affecting the integrity of the parvalbumin-expressing neuronal network..Neuropsychopharmacology2010;35:1693-707 PMCID:PMC3055473

[48] Bandelow B,Abelli M,Bourin M,Cinosi E,Domschke K,Grunblatt E,Kim YK,Masdrakis V,Nutt D,Pini S,Thibaut F,Won E,Wichniak A,Zwanzger P.Biological markers for anxiety disorders, OCD and PTSD: a consensus statement. Part II: neurochemistry, neurophysiology and neurocognition..World J Biol Psychiatry2017;18:162-214 PMCID:PMC5341771

[49] Kelmendi B,Yarnell S,Abdallah CG.PTSD: from neurobiology to pharmacological treatments..Eur J Psychotraumatol2016;7:31858 PMCID:PMC5106865

[50] Padgett CL.GABAB receptor coupling to G-proteins and ion channels..Adv Pharmacol2010;58:123-47

[51] Schuller HM,Majidi M.GABA B receptor is a novel drug target for pancreatic cancer..Cancer2008;112:767-78 PMCID:PMC3375598

[52] Al-Wadei HA,Ullah MF.Celecoxib and GABA cooperatively prevent the progression of pancreatic cancer in vitro and in xenograft models of stress-free and stress-exposed mice..PLoS One2012;7:e43376

[53] Al-Wadei MH,Schuller HM.Gamma-amino butyric acid (GABA) prevents the induction of nicotinic receptor-regulated signaling by chronic ethanol in pancreatic cancer cells and normal duct epithelia..Cancer Prev Res (Phila)2013;6:139-48 PMCID:PMC3565079

[54] Schuller HM,Majidi M.Gamma-aminobutyric acid, a potential tumor suppressor for small airway-derived lung adenocarcinoma..Carcinogenesis2008;29:1979-85 PMCID:PMC2556972

[55] Banerjee J,Al-Wadei MH.Prevention of pancreatic cancer in a hamster model by cAMP decrease..Oncotarget2016;7:44430-41 PMCID:PMC5190108

[56] Joseph J,Zaenker KS.The neurotransmitter gamma-aminobutyric acid is an inhibitory regulator for the migration of SW 480 colon carcinoma cells..Cancer Res2002;62:6467-9

[57] Pomerleau OF.Nicotine and the central nervous system: biobehavioral effects of cigarette smoking..Am J Med1992;93:2-7S

[58] Hecht SS.Progress and challenges in selected areas of tobacco carcinogenesis..Chem Res Toxicol2008;21:160-71 PMCID:PMC2556958

[59] Boo HJ,Jang HJ,Smith JK,Lee HJ,Kweon HS,Lee JJ,Lee E,Lee HY.The tobacco-specific carcinogen-operated calcium channel promotes lung tumorigenesis via IGF2 exocytosis in lung epithelial cells..Nat Commun2016;7:12961 PMCID:PMC5052689

[60] Jang HJ,Lee HJ,Lee HY.Chronic stress facilitates lung tumorigenesis by promoting exocytosis of IGF2 in lung epithelial cells..Cancer Res2016;76:6609-19

[61] Min HY,Lee HJ,Yun HJ,Smith JK,Lee HJ.Smoking-associated lung cancer prevention by blockade of the beta-adrenergic receptor-mediated insulin-like growth factor receptor activation..Oncotarget2016;7:70936-47 PMCID:PMC5342599

[62] Dasgupta P,Joshi B,Haura E.Nicotine inhibits apoptosis induced by chemotherapeutic drugs by up-regulating XIAP and survivin..Proc Natl Acad Sci U S A2006;103:6332-7 PMCID:PMC1458878

[63] Dasgupta P,Pillai S,Kovacs M,Banerjee S,Kim E,Haura E.Nicotine induces cell proliferation, invasion and epithelial-mesenchymal transition in a variety of human cancer cell lines..Int J Cancer2009;124:36-45

[64] Schuller HM.Effects of tobacco constituents and psychological stress on the beta-adrenergic regulation of non-small cell lung cancer and pancreatic cancer: implications for intervention..Cancer Biomark2013;13:133-44 PMCID:PMC3740448

[65] Schuller HM.Beta-adrenergic signaling in the development and progression of pulmonary and pancreatic adenocarcinoma..Curr Cancer Ther Rev2012;8:116-27 PMCID:PMC3691862

[66] Banerjee J,Schuller HM.Regulation of nonsmall-cell lung cancer stem cell like cells by neurotransmitters and opioid peptides..Int J Cancer2015;137:2815-24 PMCID:PMC4600645

[67] Coelho M,Brandao D,Cosentino M.β-Adrenergic modulation of cancer cell proliferation: available evidence and clinical perspectives..J Cancer Res Clin Oncol2017;143:275-91

[68] Ishida J,Ebner N.Repurposing of approved cardiovascular drugs..J Transl Med2016;14:269 PMCID:PMC5029061

[69] Melhem-Bertrandt A,Lei X,Lee RT,Sood AK,Hortobagyi GN.Beta-blocker use is associated with improved relapse-free survival in patients with triple-negative breast cancer..J Clin Oncol2011;29:2645-52 PMCID:PMC3139371

[70] Watkins JL,Nick AM,Kumar S,Matsuo K,Coleman RL,Ramirez PT.Clinical impact of selective and nonselective beta-blockers on survival in patients with ovarian cancer..Cancer2015;121:3444-51 PMCID:PMC4575637

[71] Powe DG,Zanker KS,Green AR,Entschladen F.Beta-blocker drug therapy reduces secondary cancer formation in breast cancer and improves cancer specific survival..Oncotarget2010;1:628-38

[72] Wang T,Lu HL,Cai L.Beta-adrenergic receptors: new target in breast cancer..Asian Pac J Cancer Prev2015;16:8031-9

[73] Colucci R.The role of stress and beta-adrenergic system in melanoma: current knowledge and possible therapeutic options..J Cancer Res Clin Oncol2016;142:1021-9

[74] Al-Wadei HA,Ullah MF.Gamma-amino butyric acid inhibits the nicotine-imposed stimulatory challenge in xenograft models of non-small cell lung carcinoma..Curr Cancer Drug Targets2012;12:97-106

[75] Al-Wadei MH,Al-Wadei HA.Nicotine induces self-renewal of pancreatic cancer stem cells via neurotransmitter-driven activation of sonic hedgehog signalling..Eur J Cancer2016;52:188-96 PMCID:PMC4698183

[76] Zagon IS,Smith JP.Opioid growth factor (OGF) inhibits human pancreatic cancer transplanted into nude mice..Cancer Lett1997;112:167-75

[77] Godinho RO,Pacini ES.New perspectives in signaling mediated by receptors coupled to stimulatory G protein: the emerging significance of cAMP efflux and extracellular cAMP-adenosine pathway..Front Pharmacol2015;6:58 PMCID:PMC4373373

[78] Al-Wadei HA.Non-genomic inhibitory signaling of beta-carotene in squamous cell carcinoma of the lungs..Int J Oncol2009;34:1093-8

[79] Shafer SH,Williams CL.Reduced DNA synthesis and cell viability in small cell lung carcinoma by treatment with cyclic AMP phosphodiesterase inhibitors..Biochem Pharmacol1998;56:1229-36

[80] Plummer HK3rd,Cekanova M.Expression of G-protein inwardly rectifying potassium channels (GIRKs) in lung cancer cell lines..BMC Cancer2005;5:104 PMCID:PMC1208863

[81] Rao R,Xin M.The G protein Galphas acts as a tumor suppressor in sonic hedgehog signaling-driven tumorigenesis..Cell Cycle2016;15:1325-30 PMCID:PMC4889240

[82] Schuller HM,Orloff M.Successful chemotherapy of experimental neuroendocrine lung tumors in hamsters with an antagonist of Ca2+/calmodulin..Cancer Res1990;50:1645-9

[83] Leanza L,Zoratti M,Szabo I.Pharmacological targeting of ion channels for cancer therapy: in vivo evidences..Biochim Biophys Acta2016;1863:1385-97

[84] Woods N,Coppola D,Yang S.Fendiline inhibits proliferation and invasion of pancreatic cancer cells by interfering with ADAM10 activation and beta-catenin signaling..Oncotarget2015;6:35931-48 PMCID:PMC4742152

[85] Takahara A.Cilnidipine: a new generation Ca channel blocker with inhibitory action on sympathetic neurotransmitter release..Cardiovasc Ther2009;27:124-39